Reactome | IFNAR1:TYK2 binds TYK2 inhibitors

IFNAR1:TYK2 binds TYK2 inhibitors

Stable Identifier

R-HSA-9678737

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Non-receptor tyrosine-protein kinase TYK2 binds and is inhibited by several small molecule drugs (Clark et al. 2014, Gibbons et al. 2012). TYK2 is related to the Janus kinases (JAKs) family of intracellular tyrosine kinases that play an essential role in the signaling of numerous cytokines that have been implicated in the pathogenesis of inflammatory diseases. Drugs that inhibit these kinases are thus plausible candidates for treatment of severe host inflammatory reactions to viral infection (Richardson et al. 2020, Stebbing et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
24417533	Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases Clark, JD, Flanagan, ME, Telliez, JB	J. Med. Chem.	2014
32113509	COVID-19: combining antiviral and anti-inflammatory treatments Stebbing, J, Phelan, A, Griffin, I, Tucker, C, Oechsle, O, Smith, D, Richardson, P	Lancet Infect Dis	2020
23061660	Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors Hanan, EJ, van Abbema, A, Barrett, K, Blair, WS, Blaney, J, Chang, C, Eigenbrot, C, Flynn, S, Gibbons, P, Hurley, CA, Kenny, JR, Kulagowski, J, Lee, L, Magnuson, SR, Morris, C, Murray, J, Pastor, RM, Rawson, T, Siu, M, Ultsch, M, Zhou, A, Sampath, D, Lyssikatos, JP	J. Med. Chem.	2012
32032529	Baricitinib as potential treatment for 2019-nCoV acute respiratory disease Richardson, P, Griffin, I, Tucker, C, Smith, D, Oechsle, O, Phelan, A, Stebbing, J	Lancet	2020