Reactome | SIGMAR1 [cytosol]

SIGMAR1 [cytosol]

Stable Identifier

R-HSA-9679757

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sigma non-opioid intracellular receptor 1, SGMR1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99720 SIGMAR1

Gene Names

SIGMAR1, OPRS1, SRBP, AAG8

Chain

chain:1-223

Reference Genes

BioGPS Gene:10280 SIGMAR1

COSMIC (genes):SIGMAR1 SIGMAR1

CTD Gene:10280 SIGMAR1

dbSNP Gene:10280 SIGMAR1

ENSEMBL:ENSG00000147955 SIGMAR1

ENSEMBL_homo_sapiens_GENE:ENSG00000147955.18 SIGMAR1

HGNC:8157 SIGMAR1

KEGG Gene (Homo sapiens):10280 SIGMAR1

Monarch:10280 SIGMAR1

NCBI Gene:10280 SIGMAR1

OMIM:601978 SIGMAR1

UCSC:Q99720 SIGMAR1

Reference Transcript

Other Identifiers

10280

11716141_a_at

11716142_x_at

11716143_a_at

11740062_a_at

11749330_a_at

11753548_x_at

11755295_x_at

17093507

201692_PM_at

201692_at

214484_PM_s_at

214484_s_at

3204244

3204245

3204246

3204247

3204250

3204252

3204253

3204254

3204255

3204258

3204259

3204260

33879_at

75103_at

8160857

A_23_P146637

GE59453

GO:0004985

GO:0005515

GO:0005634

GO:0005635

GO:0005637

GO:0005640

GO:0005783

GO:0005789

GO:0005811

GO:0005829

GO:0005886

GO:0006869

GO:0007399

GO:0012501

GO:0014069

GO:0016020

GO:0023052

GO:0030426

GO:0031410

GO:0031982

GO:0038003

GO:0038023

GO:0042802

GO:0042995

GO:0043226

GO:0043523

GO:0045202

GO:0045211

GO:0048856

GO:0060089

GO:0065003

GO:0070161

GO:0070207

GO:0098839

HMNXSV003018521

Hs.24447.1.S1_3p_a_at

ILMN_1717925

ILMN_2398489

PH_hs_0002153

TC09001042.hg

U79528_s_at

g5032116_3p_at

g5032116_3p_x_at

Participates

as a component of

as an input of

Cross References

RefSeq

NP_001269134.1, NP_001269138.1, NP_001269136.1, NP_001269137.1, NP_005857.1, NP_671513.1, NP_001269135.1

ZINC - World Drugs

SGMR1_HUMAN

Guide to Pharmacology - Targets

2552

OpenTargets

ENSG00000147955

ZINC - FDA approved

SGMR1_HUMAN

ZINC - Substances

SGMR1_HUMAN

ZINC - Biogenic

SGMR1_HUMAN

ZINC target

Q99720

PRO

Q99720

PDB

5HK1, 6DK1, 6DJZ, 6DK0, 5HK2

ZINC - Investigational

SGMR1_HUMAN

ZINC - Metabolites

SGMR1_HUMAN

HPA

ENSG00000147955-SIGMAR1

GeneCards

Q99720

Ensembl

ENST00000353468, ENST00000679597, ENSP00000420022, ENSG00000147955, ENSP00000277010, ENSP00000505634, ENSP00000434453, ENST00000277010, ENST00000477726

Pharos - Targets

Q99720

ZINC - Predictions - Purchasable

SGMR1_HUMAN

HMDB Protein

HMDBP07857

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449624 REP			0.788	5
UniProt:P14416 DRD2	1	DRD2 [plasma membrane] (R-HSA-390816)	0.518	5
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [azurophil granule membrane] (R-HSA-6800997)	0.508	2
UniProt:Q92847-1 GHSR			0.505	8
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.462	3

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