CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2

Stable Identifier
R-HSA-9680389
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2
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Phosphatidylinositol 3-kinase (PI3K) associated with the activated receptor for CSF1, CSF1R (M-CSFR), phosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) to yield phosphatidylinositol 3,4,5-trisphosphate (PIP3) (Saleem et al. 1995, also inferred from mouse homologs). The regulatory subunit of PI3K, PIK3R1 (p85alpha), binds phosphotyrosine-723 (721 in the mouse homologs) of CSF1R (inferred from mouse homologs). PI3K is important for proliferation, migration, and anti-inflammatory activity of macrophages (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
7737969 Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes

Saleem, A, Kharbanda, S, Kufe, D, Yuan, ZM

J. Biol. Chem. 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-3-kinase activity of CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane]

Physical Entity
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-3-kinase activity (GO:0016303)
Inferred From
Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate (Mus musculus)
Cross References
Rhea
Authored
May, B  (2020-03-27)
Reviewed
Stanley, ER  (2022-10-06)
Created
May, B  (2020-03-27)
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