ROCK1,2 bind ROCKi

Stable Identifier
R-HSA-9680443
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ROCK1,2 bind ROCKi
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Ripasudil (Glanatec), as its hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (ROCKi) used for the treatment of glaucoma and ocular hypertension in Japan (Garnock-Jones 2014). Netarsudil is a USA-approved ROCKi used to treat glaucoma and ocular hypertenstion (Sturdivant et al. 2016, Tanna & Johnson 2018).
Literature References
PubMed ID Title Journal Year
27072905 Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma

Sturdivant, JM, Royalty, SM, Laethem, CL, Lin, CW, Moore, LA, Sherman, B, Yingling, JD, Heintzelman, GR, Kopczynski, CC, deLong, MA

Bioorg. Med. Chem. Lett. 2016
30007591 Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension

Tanna, AP, Johnson, M

Ophthalmology 2018
25414122 Ripasudil: first global approval

Garnock-Jones, KP

Drugs 2014
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ROCK1,2 bind ROCKi (Xenopus tropicalis)
Authored
Jassal, B  (2020-03-27)
Reviewed
Shoichet, BK  (2020-05-14)
Created
Jassal, B  (2020-03-27)
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