nsp14 binds nsp10

Stable Identifier
R-HSA-9682544
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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nsp10 forms a stable complex with nsp14 (Bouvet et al. 2012) and serves as a co-factor for nsp14, stimulating its 3'->5' exonuclease activity (Bouvet et al. 2012, Subissi et al. 2014, Bouvet et al. 2014).
Literature References
PubMed ID Title Journal Year
22635272 RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

Canard, B, Gluais, L, Subissi, L, Decroly, E, Imbert, I, Bouvet, M

Proc. Natl. Acad. Sci. U.S.A. 2012
25074927 Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Drosten, C, Canard, B, Betzi, S, Guillemot, JC, Lécine, P, Snijder, EJ, Pfefferle, S, Lugari, A, Decroly, E, Imbert, I, Posthuma, CC, Bernard, S, Zevenhoven, JC, Bouvet, M, Morelli, X

J. Biol. Chem. 2014
25197083 One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Canard, B, Collet, A, Gorbalenya, AE, Subissi, L, Decroly, E, Imbert, I, Posthuma, CC, Zevenhoven-Dobbe, JC, Snijder, EJ

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participates
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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