nsp13 binds nsp12

Stable Identifier
R-HSA-9682626
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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nsp13 binds nsp12
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
nsp13, which functions as the viral helicase, is as a part of the human SARS coronavirus 1 (SARS-CoV-1) replication-transcription complex (RTC), where it is directly bound to nsp12, the viral RNA-dependent RNA polymerase. nsp12 increases the helicase activity of nsp13 (von Brunn et al. 2007, Adedeji et al. 2012, Jia et al. 2019).
Literature References
PubMed ID Title Journal Year
31131400 Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis

Ren, Z, Wang, J, Jia, Z, Rao, Z, Lou, Z, Yan, L, Guo, J, Wu, L, Zheng, L, Zhang, L, Ming, Z

Nucleic Acids Res. 2019
17520018 Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome

Simpson, JC, Baric, R, von Brunn, A, Pepperkok, R, Teepe, C, Zimmer, R, Friedel, CC, Roberts, R, Haas, J

PLoS ONE 2007
22615777 Mechanism of nucleic acid unwinding by SARS-CoV helicase

Sarafianos, SG, Eoff, RL, te Velthuis, AJ, Adedeji, AO, Singh, K, Marchand, B, Snijder, EJ, Weiss, S

PLoS ONE 2012
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Orlic-Milacic, M  (2020-04-30)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-04-13)
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