The majority of nucleocapsid protein (N) is serine-phosphorylated in the cytosol and, possibly, in the nucleus where it gets immediately transported to the cytosol. Phosphorylation is catalyzed by glycogen synthase kinase 3 (GSK3A and GSK3B) and several other host cell kinases (Surjit et al, 2005; Wu et al. 2009). GSK3-mediated phosphorylation of the N protein is needed for efficient replication of viral genomic RNA (Wu et al. 2009).
Mishra, RN, Kumar, R, Reddy, MK, Chow, VT, Surjit, M, Lal, SK
Wu, CH, Tsay, YG, Chen, PJ, Kao, CL, Kuo, TJ, Chen, DS, Chen, YS, Wang, SH, Shieh, YH, Yeh, SH
protein serine/threonine kinase activity of GSK3 [cytosol]
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