Trimmed spike protein binds to calnexin

Stable Identifier
R-HSA-9683772
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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Trimmed spike protein binds to calnexin
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Calnexin transiently binds the unfolded spike protein and prevents its aggregation and premature degradation, ensuring its correct folding (Fukushi et al, 2012)
Literature References
PubMed ID Title Journal Year
22915798 Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus

Miyoshi-Akiyama, T, Sasazuki, T, Yoshinaka, Y, Kirikae, T, Fukushi, M, Hatakeyama, S, Ishizaka, Y, Matsuoka, Y

J. Virol. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

unfolded protein binding activity of CANX [endoplasmic reticulum lumen]

Physical Entity
CANX [endoplasmic reticulum lumen] (Homo sapiens)
Activity
unfolded protein binding (GO:0051082)
Orthologous Events
Trimmed spike protein binds to calnexin (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-08)
Created
Stephan, R  (2020-04-17)
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