3CLp cleaves pp1a

Stable Identifier
R-HSA-9684273
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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3CLp cleaves pp1a
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Main protease cleaves all cleavage sites of pp1a and ppa1b starting with nsp4/5, thus cleaving itself, and all the cytosolic RTC proteins (Fan et al, 2004)
Literature References
PubMed ID Title Journal Year
14561748 Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase

Chen, J, Liu, Y, Lai, B, Wei, P, Ma, L, Feng, Q, Fan, K, Lai, L, Pei, J, Huang, C, Chen, S

J. Biol. Chem. 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of 3CLp dimer [cytosol]

Physical Entity
3CLp dimer [cytosol] (Human SARS coronavirus)
Activity
cysteine-type endopeptidase activity (GO:0004197)
This event is regulated
Negatively by
Regulator
3CLp dimer:α-Ketoamides [cytosol] (Human SARS coronavirus)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-14)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Stephan, R  (2020-04-21)
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