Nucleoprotein is ADP-ribosylated

Stable Identifier
R-HSA-9686061
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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Nucleoprotein is ADP-ribosylated
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Nucleoprotein (N) is ADP-ribosylated. The modification is maintained both in the cell and in virions (Grunewald et al, 2018). Members of the protein mono-ADP-ribosyltransferase (PARP) enzyme family are thought to catalyze this reaction (Fehr et al. 2020).
Literature References
PubMed ID Title Journal Year
32029454 The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions

Aikawa, M, Fehr, AR, Higashi, H, Kerr, CM, Mukai, S, Singh, SA

Genes Dev. 2020
29199039 The coronavirus nucleocapsid protein is ADP-ribosylated

Perlman, S, Grunewald, ME, Fehr, AR, Athmer, J

Virology 2018
Participants
Input
Output
Participates
as an event of
Catalyst Activity

NAD+ ADP-ribosyltransferase activity of PARPs [cytosol]

Physical Entity
PARPs [cytosol] (Homo sapiens)
Activity
NAD+ ADP-ribosyltransferase activity (GO:0003950)
Orthologous Events
Nucleoprotein is ADP-ribosylated (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-28)
Created
Stephan, R  (2020-04-28)
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