CASP3 cleaves GSDMD

Stable Identifier
R-HSA-9686088
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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During apoptosis, activated caspase-3 (CASP3) and to a lesser degree CASP7 inactivate gasdermin D (GSDMD) by cleaving GSDMD at position D87 generating p20 (GSDMD(1-87)) and p43 (GSDMD(88-484)) fragments (Taabazuing CY et al. 2017). This cleavage site is evolutionarily conserved and lies within the N-terminal fragment (p30, GSDMD(1-275)) that forms membrane pores. Proteolysis at this site renders GSDMD incapable of activating pyroptosis (Taabazuing CY et al. 2017). This pathway does not seem to play a key role during animal development as wild-type and Gsdmd-deficient mice both develop normally.

Literature References
PubMed ID Title Journal Year
28392147 Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

Taabazuing, CY, Okondo, MC, Bachovchin, DA

Cell Chem Biol 2017
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Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

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