IAV NS1 binds MLKL

Stable Identifier
R-HSA-9686343
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IAV NS1 binds MLKL
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Co-immunoprecipitation assays in influenza A virus (IAV)-infected human leukemia monocytic THP1 cell, as well as NS1-transfected human embryonic kidney (HEK293) cells showed that viral NS1 interacts with mixed-lineage kinase domain-like protein (MLKL) in an RNA-dependent manner (Gaba A et al. 2019). The second brace helix of MLKL is responsible for interacting with NS1 (Gaba A et al. 2019). The interaction of NS1 with MLKL is thought to increased MLKL membrane translocation. Moreover, the MLKL:NS1 interaction enhanced NLRP3 inflammasome activation and increases IL-1β processing and secretion (Gaba A et al. 2019).
Literature References
PubMed ID Title Journal Year
30355688 The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation

Zhou, Y, Liu, G, Lu, Y, Park, HS, Xu, F, Gaba, A

J. Virol. 2019
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Shamovsky, V  (2020-05-21)
Reviewed
Murphy, JM  (2020-08-28)
D'Eustachio, P  (2020-06-26)
Created
Shamovsky, V  (2020-04-30)
Cite Us!