Reactome | CDK2:CCNA phosphorylates TERF2

CDK2:CCNA phosphorylates TERF2

Stable Identifier

R-HSA-9686521

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Outside of the S phase of the cell cycle, the shelterin complex subunit TERF2 (TRF2) is phosphorylated on serine residue S365. This phosphorylation is performed by the complex of CDK2 and cyclin A (CCNA). Phosphorylation of TERF2 at S365 prevents association of RTEL1 with telomeres, thus protecting t-loops from promiscuous unwinding and inappropriate activation of ATM (Sarek et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
31723267	CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle Snijders, AP, Cesare, AJ, Flynn, HR, Boulton, SJ, Zheng, XF, Margalef, P, Ruis, P, Chowdhury, D, Borel, V, Sarek, G, Van Ly, D, Kotsantis, P	Nature	2019