Reactome | OPTN [cytosol]

OPTN [cytosol]

Stable Identifier

R-HSA-9687907

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Optineurin, Huntingtin-interacting protein 7

Locations in the PathwayBrowser for interactor UniProt:Q96PU8 QKI

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
        
        Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation (Homo sapiens)
        
        OPTN binds TBK1 within the activated TLR3 complex (Homo sapiens)
        
        OPTN [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
        
        Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
        
        OPTN binds TBK1 within the activated TLR4 complex (Homo sapiens)
        
        OPTN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96CV9 OPTN

Gene Names

OPTN, FIP2, GLC1E, HIP7, HYPL, NRP

Chain

chain:1-577

Reference Genes

BioGPS Gene:10133 OPTN

COSMIC (genes):OPTN OPTN

CTD Gene:10133 OPTN

dbSNP Gene:10133 OPTN

ENSEMBL:ENSG00000123240 OPTN

ENSEMBL_homo_sapiens_GENE:ENSG00000123240.17 OPTN

HGNC:17142 OPTN

KEGG Gene (Homo sapiens):10133 OPTN

Monarch:10133 OPTN

NCBI Gene:10133 OPTN

OMIM:602432 OPTN

UCSC:Q96CV9 OPTN

Reference Transcript

Other Identifiers

10133

11736020_a_at

11745271_x_at

11757341_s_at

16702547

202073_PM_at

202073_at

202074_PM_s_at

202074_s_at

3235730

3235731

3235732

3235737

3235738

3235739

3235742

3235743

3235744

3235746

3235749

3235750

3235752

3235755

3235757

3235759

3235761

3235762

3235767

3235768

3235769

3235771

41742_s_at

41743_i_at

41744_at

7926239

A_14_P127414

A_23_P1461

A_33_P3333317

GE82633

GE84788

GE85528

GO:0000139

GO:0001920

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005773

GO:0005776

GO:0005794

GO:0005802

GO:0005829

GO:0006914

GO:0007005

GO:0007030

GO:0007165

GO:0008104

GO:0008219

GO:0010508

GO:0016192

GO:0023052

GO:0030674

GO:0031410

GO:0031593

GO:0034067

GO:0034620

GO:0042802

GO:0043001

GO:0043122

GO:0043124

GO:0043226

GO:0045087

GO:0046872

GO:0048471

GO:0050829

GO:0055037

GO:0055038

GO:0060090

GO:0061734

GO:0070530

GO:0072659

GO:0090161

GO:0098542

GO:1904417

HMNXSV003045739

Hs.278898.0.A2_3p_at

ILMN_2381899

PH_hs_0024518

TC10000097.hg

g11415041_3p_s_at

Participates

as a component of

as an input of

Other forms of this molecule

OPTN [recycling endosome membrane]

p-S177-OPTN [nucleoplasm]

p-S177-OPTN [cytosol]

OPTN [Golgi membrane]

p-S177,S473,S513-OPTN [cytosol]

Inferred To

optn [cytosol] (Xenopus tropicalis)

OPTN [cytosol] (Bos taurus)

OPTN [cytosol] (Canis familiaris)

OPTN [cytosol] (Danio rerio)

OPTN [cytosol] (Drosophila melanogaster)

OPTN [cytosol] (Gallus gallus)

OPTN [cytosol] (Mus musculus)

OPTN [cytosol] (Rattus norvegicus)

OPTN [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_068815.2, NP_001008214.1, NP_001008213.1, NP_001008212.1

OpenTargets

ENSG00000123240

GeneCards

Q96CV9

HPA

ENSG00000123240-OPTN

Ensembl

ENST00000263036, ENST00000378752, ENST00000378764, ENST00000378757, ENSP00000263036, ENSP00000368027, ENSP00000368022, ENSP00000368032, ENSP00000368040, ENSG00000123240, ENST00000378747, ENSP00000368021, ENST00000378748

PRO

Q96CV9

Pharos - Targets

Q96CV9

Orphanet

16595

PDB

2LO4, 5EOF, 3VTW, 5EOA, 5B83, 2LUE, 5AAZ, 7CZM, 3VTV

Interactors (197)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.966	22
UniProt:Q9Y3C0 WASC3			0.951	17
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.928	16
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.926	17
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.824	15
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.805	9
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.795	8
UniProt:Q9NTZ6 RBM12			0.782	7
UniProt:Q9HA65 TBC1D17	1	TBC1D17 [recycling endosome] (R-HSA-8854149)	0.74	7
UniProt:Q9BS34 ZNF670	1	ZNF670 [nucleoplasm] (R-HSA-2248887)	0.718	6
UniProt:Q15038 DAZP2			0.718	6
UniProt:Q8IYU2 HACE1	1	HACE1 [cytosol] (R-HSA-8851654)	0.693	15
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.675	4
UniProt:Q8N448 LNX2			0.668	3
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.666	4
UniProt:P61006 RAB8A	6	GGC-RAB8A [cytoplasmic vesicle membrane] (R-HSA-1445093) RAB8A [recycling endosome membrane] (R-HSA-8854145) GGC-RAB8A [trans-Golgi network membrane] (R-HSA-8876082) GGC-RAB8A [cytosol] (R-HSA-8874063) RAB8A [Golgi membrane] (R-HSA-2562535) RAB8A [cytosol] (R-HSA-5623399)	0.633	4
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.615	3
UniProt:Q29122 MYO6			0.598	3
UniProt:P54845-1 NRL			0.589	6
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.558	7
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:O95340 PAPSS2	4	PAPSS2 T48R [cytosol] (R-HSA-3621821) PAPSS2 S438* [cytosol] (R-HSA-3621745) PAPSS2 R329* [cytosol] (R-HSA-3621810) PAPSS2 [cytosol] (R-HSA-3009048)	0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q15797 SMAD1	4	Ub-SMAD1 [cytosol] (R-HSA-6782768) SMAD1 [cytosol] (R-HSA-201468) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483)	0.556	3
UniProt:Q9Y574-2 Q9Y5742			0.556	3
UniProt:Q96RQ9 IL4I1	1	IL4I1 [extracellular region] (R-HSA-2160467)	0.556	3
UniProt:Q9HBL8 NMRAL1	1	NMRAL1 [cytosol] (R-HSA-6810879)	0.556	3
UniProt:Q71DI3 H3C15	20	2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) Me1K5-HIST2H3A [nucleoplasm] (R-HSA-9677679) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803)	0.556	3
UniProt:Q86VR2 RETR3			0.556	3
UniProt:Q9BWG1 Q9BWG1			0.556	3
UniProt:Q96G97-4 BSCL2			0.556	3
UniProt:Q49A26-4 GLYR1			0.556	3
UniProt:P52306-4 RAP1GDS1			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:P40454 PTPA1			0.556	3
UniProt:Q9NWS9-2 ZNF446			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q9P2R7 SUCLA2	1	SUCLA2 [mitochondrial matrix] (R-HSA-156624)	0.556	3
UniProt:Q92185 ST8SIA1	1	ST8SIA1 [Golgi membrane] (R-HSA-4086283)	0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:Q0P5P2 CQ067			0.556	3
UniProt:Q6NXG1-3 Q6NXG13			0.556	3
UniProt:Q9C0D3 ZY11B			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P08758 ANXA5	2	ANXA5 [extracellular region] (R-HSA-8862986) ANXA5 [cytosol] (R-HSA-8862945)	0.556	3
UniProt:Q9ULX5 RN112			0.556	3
UniProt:P15169 CPN1	1	CPN1 [extracellular region] (R-HSA-8852824)	0.556	3
UniProt:P61026 RAB10	5	GGC-RAB10 [cytoplasmic vesicle membrane] (R-HSA-8876076) GGC-RAB10 [cytosol] (R-HSA-8873783) RAB10 [cytosol] (R-HSA-8873669) RAB10 [plasma membrane] (R-HSA-6804816) RAB10 [secretory granule membrane] (R-HSA-6804788)	0.556	3
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.556	3
UniProt:O95671 ASML			0.556	3
UniProt:Q8TBB0 THAP6			0.556	3
UniProt:Q9UBT3 DKK4	2	DKK4 [early endosome membrane] (R-HSA-5368466) DKK4 [extracellular region] (R-HSA-3769327)	0.556	3
UniProt:Q9UDX5 MTFP1			0.556	3
UniProt:O60927 PP1RB			0.556	3
UniProt:P55058-2 PLTP	1	PLTP-2 [extracellular region] (R-HSA-194203)	0.556	3
UniProt:P51116 FXR2			0.556	3
UniProt:P28347-2 TEAD1			0.556	3
UniProt:A1A4Y4 IRGM			0.556	3
UniProt:Q8N1C3 GBRG1			0.556	3
UniProt:P10276-2 RARA			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
UniProt:Q9Y2X9 ZN281			0.556	3
UniProt:Q8IZS5 OFCC1			0.556	3
UniProt:Q8IVL6-2 P3H3			0.556	3
UniProt:Q53HV7-2 SMUG1			0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
UniProt:Q96HQ0 ZNF419	1	ZNF419 [nucleoplasm] (R-HSA-1247523)	0.556	3
UniProt:A2RU56 A2RU56			0.556	3
UniProt:Q0P5N6 ARL16			0.556	3
UniProt:P17021 ZNF17	1	ZNF17 [nucleoplasm] (R-HSA-974984)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q9UQ53 MGAT4B	1	MGAT4B [Golgi membrane] (R-HSA-975921)	0.556	3
UniProt:Q8N302-2 Q8N3022			0.556	3
UniProt:Q8N205-2 SYNE4			0.556	3
UniProt:Q8N1Y9 YI025			0.556	3
UniProt:Q86UD4 ZN329			0.556	3
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.556	3
UniProt:P26639 TARS1	1	TARS [cytosol] (R-HSA-379682)	0.556	3
IntAct:EBI-25911396 CCSB			0.556	3
UniProt:Q9UIR0-4 Q9UIR04			0.556	3
UniProt:Q99732 LITAF			0.556	3
UniProt:Q8TBE1 CNIH3	3	CNIH3 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689785) CNIH3 [ER to Golgi transport vesicle membrane] (R-HSA-5689783) CNIH3 [endoplasmic reticulum membrane] (R-HSA-5689443)	0.556	3
UniProt:P01123	20	phospho-p-T191-RAB1B [Golgi membrane] (R-SCE-2422374) phospho-p-T195-RAB1A [Golgi membrane] (R-SCE-2172190) RAB1B [Golgi membrane] (R-SCE-2422381) RAB1A [Golgi membrane] (R-SCE-2167938) RAB1B [cytosol] (R-SCE-5685727) RAB1A [cytosol] (R-SCE-5685725) RAB1A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-6807766) RAB1B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-6807768) RAB1A [transport vesicle] (R-SCE-6808796) RAB1B [transport vesicle] (R-SCE-6808799) RAB43 [cytosol] (R-SCE-6813902) RAB19 [cytosol] (R-SCE-8873714) GGC-RAB19 [cytosol] (R-SCE-8873773) GGC-RAB43 [cytosol] (R-SCE-8874038) GGC-RAB1B [cytosol] (R-SCE-8870426) GGC-RAB1A [cytosol] (R-SCE-8870424) GGC-RAB1B [transport vesicle membrane] (R-SCE-8877470) GGC-RAB1A [transport vesicle membrane] (R-SCE-8877472) RAB43 [trans-Golgi network membrane] (R-SCE-6814810) RAB1A [endoplasmic reticulum membrane] (R-SCE-6810974)	0.556	3
UniProt:Q96EY8 MMAB	4	MMAB E193K [mitochondrial matrix] (R-HSA-3322150) MMAB R191W [mitochondrial matrix] (R-HSA-3322112) MMAB R186W [mitochondrial matrix] (R-HSA-3322128) MMAB [mitochondrial matrix] (R-HSA-2980970)	0.556	3
UniProt:P24666-2 P246662			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:P17029 ZKSCAN1	1	ZKSCAN1 [nucleoplasm] (R-HSA-975013)	0.556	3
UniProt:P10074 TZAP			0.556	3
UniProt:P50749 RASF2			0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:Q02556 IRF8	1	IRF8 [cytosol] (R-HSA-1015685)	0.556	3
UniProt:Q32M92-2 Q32M922			0.556	3
UniProt:Q3KNW7 Q3KNW7			0.556	3
UniProt:Q496A3 SPAS1			0.556	3
UniProt:Q96EZ4 MYEOV			0.556	3
UniProt:Q96LL4 CH048			0.556	3
UniProt:Q8N5A5-2 ZGPAT			0.556	3
IntAct:EBI-25910725 CCSB			0.556	3
UniProt:P49450 CENPA	2	CENPA [nucleoplasm] (R-HSA-606322) CENPA [cytosol] (R-HSA-375317)	0.556	3
UniProt:Q8IV33 K0825			0.556	3
UniProt:P23297 S100A1	1	S100A1 [extracellular region] (R-HSA-6805991)	0.556	3
UniProt:Q8IZQ1-2 WDFY3			0.556	3
UniProt:O15195-2 O151952			0.556	3
UniProt:Q8WVJ2 NUDC2			0.556	3
IntAct:EBI-25911021 CCSB			0.556	3
UniProt:P07384 CAPN1	4	CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284)	0.556	3
UniProt:Q96PU8 QKI	2	QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466) QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546)	0.556	3
IntAct:EBI-25910851 CCSB			0.556	3
UniProt:O00203 AP3B1	4	AP3B1 [Golgi membrane] (R-HSA-434335) AP3B1 [cytoplasmic vesicle membrane] (R-HSA-434197) AP3B1(1-859)-BRAF(381-766) fusion [cytosol] (R-HSA-6802269) AP3B1(1-859)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802516)	0.556	3
UniProt:I6L9D0 I6L9D0			0.556	3
UniProt:P49459 UBE2A	3	UBE2A [cytosol] (R-HSA-947617) Ub-C88-UBE2A [nucleoplasm] (R-HSA-8864186) UBE2A [nucleoplasm] (R-HSA-8852048)	0.556	3
UniProt:Q5VZL5-4 ZMYM4			0.556	3
UniProt:Q6PCB6 ABHD17C	1	ABHD17C [plasma membrane] (R-HSA-9647774)	0.556	3
UniProt:P04440 HLA-DPB1	9	HLA class II histocompatibility antigen, DP [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130709) HLA class II histocompatibility antigen, DP [ER to Golgi transport vesicle membrane] (R-HSA-2130688) HLA class II histocompatibility antigen, DP [Golgi membrane] (R-HSA-2214364) HLA class II histocompatibility antigen, DP [trans-Golgi network membrane] (R-HSA-2130397) HLA class II histocompatibility antigen, DP [transport vesicle membrane] (R-HSA-2130533) HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane] (R-HSA-2130390) HLA class II histocompatibility antigen, DP [endocytic vesicle membrane] (R-HSA-2130419) HLA class II histocompatibility antigen, DP [lysosomal membrane] (R-HSA-2130601) HLA class II histocompatibility antigen, DP [plasma membrane] (R-HSA-197648)	0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:A2RRN7 A2RRN7			0.556	3
UniProt:Q96B67 ARRD3			0.556	3
UniProt:P61296-2 HAND2			0.556	3
UniProt:Q5TZF3-1 Q5TZF31			0.556	3
UniProt:Q9BUH6 PAXX			0.556	3
IntAct:EBI-25911486 CCSB			0.556	3
UniProt:Q13702-2 Q137022			0.556	3
UniProt:Q3SX64 CMA1D			0.556	3
UniProt:Q6IE81-3 JADE1			0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:P78410 BTN3A2	1	BTN3A2 [plasma membrane] (R-HSA-197605)	0.556	3
UniProt:Q9NY26 SLC39A1	1	SLC39A1 [plasma membrane] (R-HSA-442329)	0.556	3
UniProt:O60711 LPXN			0.556	3
IntAct:EBI-25910368 CCSB			0.556	3
UniProt:P18206-2 VCL			0.556	3
IntAct:EBI-25910801 CCSB			0.556	3
UniProt:A4FUJ8 A4FUJ8			0.556	3
UniProt:Q6ZS81-2 Q6ZS812			0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:Q2NKQ1-4 SGSM1			0.556	3
UniProt:Q9P209 CEP72	1	CEP72 [cytosol] (R-HSA-380321)	0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:Q9NR11-2 ZNF302			0.556	3
UniProt:Q9Y5L3 ENTPD2	1	ENTPD2 [plasma membrane] (R-HSA-8851088)	0.556	3
UniProt:Q12904-2 AIMP1			0.556	6
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q96G46 DUS3L			0.556	3
UniProt:P28566 HTR1E	1	HTR1E [plasma membrane] (R-HSA-390960)	0.556	3
UniProt:Q9Y6Q9-5 NCOA3			0.556	3
UniProt:Q08499-8 PDE4D			0.556	3
UniProt:Q9BUL9 RPP25	1	RPP25 [nucleoplasm] (R-HSA-5696782)	0.556	3
UniProt:Q8TDB4 HUMMR			0.556	3
UniProt:P40302	1	PRE5 [cytosol] (R-SCE-68724)	0.556	3
UniProt:P54274-2 TERF1			0.556	3
IntAct:EBI-25910474 CCSB			0.556	3
UniProt:Q86TI2-2 Q86TI22			0.556	3
UniProt:Q9Y2D5 PLAK2			0.556	3
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.556	3
UniProt:Q8TD17 ZNF398	1	ZNF398 [nucleoplasm] (R-HSA-1247512)	0.556	3
IntAct:EBI-25851697 CCSB			0.556	3
UniProt:A0A1C3PI11 A0A1C3PI11			0.556	3
UniProt:Q9BV73 CEP250	1	CEP250 [cytosol] (R-HSA-380263)	0.556	3
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:Q969S8 HDAC10	1	HDAC10 [nucleoplasm] (R-HSA-351579)	0.556	3
UniProt:P07225 PROS1	8	11xCbxE-PROS1 [platelet alpha granule lumen] (R-HSA-349762) 11xCbxE-PROS1 [extracellular region] (R-HSA-202772) 11xCbxE-PROS1 [plasma membrane] (R-HSA-141004) PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159758) 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159770) 11xCbxE-PROS1(25-676) [Golgi membrane] (R-HSA-159850) PROS1(25-41) [Golgi lumen] (R-HSA-159792) 11xCbxE-PROS1 [Golgi membrane] (R-HSA-159865)	0.556	3
UniProt:Q9Y221 NIP7	1	NIP7 [nucleoplasm] (R-HSA-6797236)	0.556	3
UniProt:Q14894 CRYM	1	CRYM [peroxisomal matrix] (R-HSA-5693333)	0.556	3
UniProt:P52888 THOP1	1	THOP1 [cytosol] (R-HSA-8940604)	0.556	3
UniProt:Q9NRA0 SPHK2	1	SPHK2 [cytosol] (R-HSA-428236)	0.556	3
UniProt:Q9NWF9 RNF216	1	RNF216 [cytosol] (R-HSA-936043)	0.556	3
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q96QE2 SLC2A13	1	SLC2A13 [plasma membrane] (R-HSA-429102)	0.556	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.556	3
UniProt:Q6YHU6 THADA	1	THADA [cytoplasm] (R-HSA-8870282)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P51582 P2RY4	1	P2RY4 [plasma membrane] (R-HSA-417861)	0.556	3
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:Q9H6R3 ACSS3	1	ACSS3 [mitochondrial matrix] (R-HSA-5696385)	0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:Q8TBZ3 WDR20	1	WDR20 [nucleoplasm] (R-HSA-5696932)	0.527	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P61007	5	RAB8A [recycling endosome membrane] (R-CFA-8854145) GGC-RAB8A [trans-Golgi network membrane] (R-CFA-8876082) GGC-RAB8A [cytosol] (R-CFA-8874063) RAB8A [cytosol] (R-CFA-5623399) RAB8A [Golgi membrane] (R-CFA-2562535)	0.527	2
UniProt:O75923 DYSF	1	DYSF [cytoplasmic vesicle membrane] (R-HSA-5263626)	0.505	3
UniProt:Q00013 MPP1	1	MPP1 [plasma membrane] (R-HSA-420423)	0.499	2
UniProt:Q99IB8-PRO_0000045599			0.488	3
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.483	2
UniProt:Q13023 AKAP6			0.454	2
UniProt:Q14BN4 SLMAP			0.454	2
UniProt:Q9UNH7 SNX6			0.454	2
UniProt:Q8WZ42 TTN	2	TTN [extracellular region] (R-HSA-350729) TTN [cytosol] (R-HSA-350726)	0.454	2
UniProt:Q03001 DST	1	DST [plasma membrane] (R-HSA-447008)	0.454	2
UniProt:P04275 VWF	20	VWF(23-763) [platelet alpha granule lumen] (R-HSA-114662) VWF Q1402P (764-2813) [extracellular region] (R-HSA-9823711) VWF S1394F (764-2813) [extracellular region] (R-HSA-9823696) VWF S1387I (764-2813) [extracellular region] (R-HSA-9823697) VWF S1358N (764-2813) [extracellular region] (R-HSA-9823703) VWF G1579R (764-1605) [extracellular region] (R-HSA-9852786) VWF C1099P (764-1605) [extracellular region] (R-HSA-9852778) VWF I1568N (764-1605) [extracellular region] (R-HSA-9852790) VWF G1631D (1606-2813) [extracellular region] (R-HSA-9852788) VWF Y1584C (764-1605) [extracellular region] (R-HSA-9852765) VWF I1568N (764-2813) [extracellular region] (R-HSA-9844203) VWF C1099P (764-2813) [extracellular region] (R-HSA-9844221) VWF G1631D (764-2813) [extracellular region] (R-HSA-9844230) VWF Y1584C (764-2813) [extracellular region] (R-HSA-9844202) VWF G1579R (764-2813) [extracellular region] (R-HSA-9844214) VWF (1606-2813) [extracellular region] (R-HSA-9822534) VWF(764-1605) [extracellular region] (R-HSA-9822545) VWF W1745C (764-2813) [extracellular region] (R-HSA-9823611) VWF H1786D (764-2813) [extracellular region] (R-HSA-9823634) VWF S1783A (764-2813) [extracellular region] (R-HSA-9823588)	0.454	2

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