Reactome | MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]

MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-9689606

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

PALS1/MPP5, MAGUK p55 subfamily member 5, MPP5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3

Expand all

External Reference Information

External Reference

UniProt:Q8N3R9 MPP5

Gene Names

MPP5, PALS1

Chain

chain:1-675

Reference Genes

BioGPS Gene:64398 MPP5

COSMIC (genes):MPP5 MPP5

CTD Gene:64398 MPP5

dbSNP Gene:64398 MPP5

ENSEMBL:ENSG00000072415 MPP5

ENSEMBL_homo_sapiens_GENE:ENSG00000072415.10 MPP5

HGNC:18669 MPP5

KEGG Gene (Homo sapiens):64398 MPP5

Monarch:64398 MPP5

NCBI Gene:64398 MPP5

OMIM:606958 MPP5

UCSC:Q8N3R9 MPP5

Reference Transcript

Other Identifiers

11718947_a_at

11718948_a_at

11718949_a_at

11718950_s_at

11718951_a_at

16785606

219321_PM_at

219321_at

226092_PM_at

226092_at

3541074

3541075

3541076

3541080

3541081

3541085

3541090

3541091

3541092

3541093

3541100

3541101

3541106

3541108

3541110

3541111

3541114

3541116

3541117

3541119

3541120

3541122

3541126

3541127

3541128

3541129

3541130

3541134

64398

65177_at

73186_at

7975203

A_14_P102313

A_23_P99536

A_24_P347458

A_33_P3248967

GE54852

GE82700

GO:0000166

GO:0002011

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005793

GO:0005794

GO:0005886

GO:0005912

GO:0005923

GO:0007009

GO:0007163

GO:0008104

GO:0010467

GO:0012505

GO:0016020

GO:0016324

GO:0016332

GO:0017015

GO:0019904

GO:0021954

GO:0021987

GO:0023052

GO:0030154

GO:0030424

GO:0032287

GO:0032288

GO:0032991

GO:0033116

GO:0035749

GO:0035750

GO:0042802

GO:0042995

GO:0043204

GO:0043219

GO:0043220

GO:0043226

GO:0043296

GO:0045177

GO:0045197

GO:0048699

GO:0048856

GO:0061024

GO:0070062

GO:0070161

GO:0072659

HMNXSV003021778

Hs.13399.0.S1_3p_at

ILMN_1750689

PH_hs_0006032

TC14000403.hg

g11968024_3p_at

g11968024_3p_x_at

Participates

as a component of

as an input of

Other forms of this molecule

MPP5 [plasma membrane]

Cross References

RefSeq

NP_001243479.1, XP_005268060.1, XP_011535388.1, NP_071919.2, XP_011535389.1

OpenTargets

ENSG00000072415

GeneCards

Q8N3R9

HPA

ENSG00000072415-PALS1

Ensembl

ENST00000676464, ENST00000678380, ENST00000555925, ENST00000677382, ENSP00000503321, ENSP00000451488, ENSP00000503322, ENSG00000072415, ENSP00000261681, ENST00000261681, ENSP00000503517, ENST00000677835, ENSP00000503713

PRO

Q8N3R9

Pharos - Targets

Q8N3R9

PDB

7NTK, 3UIT, 4UU6, 7QCS, 4UU5, 7NTJ, 4WSI, 1Y76, 7M4R

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14910 LIN7A	2	LIN7A [plasma membrane] (R-HSA-5216076) LIN7A [transport vesicle membrane] (R-HSA-9610413)	0.871	10
UniProt:Q4VCS5 AMOT			0.802	7
UniProt:P0DTC4 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [virion membrane] (R-COV-9698416)	0.798	6
UniProt:Q8NI35 PATJ	1	PATJ [plasma membrane] (R-HSA-420011)	0.784	6
UniProt:P82279 CRUM1			0.779	5
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.742	6
UniProt:P59637 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9683652) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9683767) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683626) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683597) nascent E [endoplasmic reticulum lumen] (R-COV-9683684) Ub-3xPalmC-E [Golgi membrane] (R-COV-9683694) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698721) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698722) Ub-3xPalmC-E [virion membrane] (R-COV-9698716)	0.683	4
UniProt:P46937 YAP1	8	p-Y407-YAP1 [cytosol] (R-HSA-9865208) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.671	5
UniProt:Q9HAP6 LIN7B	2	LIN7B [plasma membrane] (R-HSA-5216107) LIN7B [transport vesicle membrane] (R-HSA-9610415)	0.666	5
UniProt:Q96JB8 MPP4			0.625	5
UniProt:Q8N3R9 MPP5	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.592	2
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.581	4
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
IntAct:EBI-23645769 CCSB ORF ID			0.556	3
UniProt:Q6PI77 GASP3			0.556	3
UniProt:Q9NY99-2 Q9NY992			0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9Y2H0-1 DLGAP4			0.556	3
UniProt:A0A286YEY3 A0A286YEY3			0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:O95954 FTCD	1	FTCD [cytosol] (R-HSA-70907)	0.556	3
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O75970 MPDZ			0.527	2
UniProt:Q8IY63 AMOTL1	1	AMOTL1 [cytosol] (R-HSA-2028603)	0.527	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.527	4
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.488	2

Cite Us!