A sequence comparison of the E proteins of the pathogenic human CoVs, SARS‑CoV‑1, MERS‑CoV, and SARS‑CoV‑2, demonstrated a very high sequence similarity between SARS‑CoV‑1 E and SARS‑CoV‑2 E (Grifoni A et al. 2020; Schoeman D & Fielding BC 2020; Hassan SS et al. 2020). This similarity is not shared with the MERS‑CoV E protein (Schoeman D & Fielding BC 2020). In silico modelling analyses of E proteins conformation and docking suggested a strengthened binding of SARS‑CoV‑2 E protein with the tight junction‑associated MPP5 protein (De Maio F et al. 2020). Equilibrium and kinetic binding experiments between peptides mimicking the E protein of SARS‑CoV‑1 and SARS‑CoV‑2 and the PDZ domain of MPP5 further support that the binding affinity of SARS‑CoV‑2 E protein for MPP5 is increased compared to SARS-CoV-1 E protein (Toto A et al. 2020).
Margolis, B, Liu, CJ, Teoh, KT, Bruzzone, R, Nal, B, Peiris, JS, Chan, WL, Siu, YL, Schlüter, MA
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