RHOB binds effectors on endosomes

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Endosome-bound activated RHOB (RHOB:GTP) recruits the following effectors:
DIAPH1 (Fernandez-Borja et al. 2005; Higashi et al. 2008)
DIAPH3 (Wallar et al. 2007)
RHPN2 (Mircescu et al. 2002).

Literature References
PubMed ID Title Journal Year
15944396 RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1

Janssen, L, Fernandez-Borja, M, Neefjes, J, Hordijk, P, Verwoerd, D

J. Cell. Sci. 2005
17198702 RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking

Wallar, BJ, Alberts, AS, Deward, AD, Resau, JH

Exp. Cell Res. 2007
12473120 Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP

Steuve, S, Dumont, JE, Mircescu, H, Degraef, C, Pirson, I, Mellor, H, Maenhaut, C, Savonet, V

Eur. J. Biochem. 2002
18218625 Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets

Ikeda, T, Kondo, H, Horiuchi, H, Okuda, T, Okawa, K, Shirakawa, R, Higashi, T, Kita, T, Kawato, M, Nureki, O, Fukai, S, Horiguchi, M

J. Biol. Chem. 2008
Orthologous Events
Cite Us!