Reactome | RAC1 binds effectors at the ER membrane

RAC1 binds effectors at the ER membrane

Stable Identifier

R-HSA-9691174

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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In its GTP bound active form, endoplasmic reticulum membrane associated RAC1 binds to and activates KTN1 (Hotta et al. 1996).

The following endoplasmic reticulum proteins have been identified as putative RAC1 effectors in the high throughput screen by Bagci et al. 2020 and are annotated as candidate RAC1 effectors:
EMD (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
LEMD3 (Bagci et al. 2020)
VRK2 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP	Nat. Cell Biol.	2020
8769096	Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor Mino, A, Kohno, H, Hotta, K, Takai, Y, Tanaka, K	Biochem. Biophys. Res. Commun.	1996