KCNJ11:ABCC9 binds nicorandil

Stable Identifier
R-HSA-9691566
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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KCNJ11:ABCC9 binds nicorandil
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Nicorandil, a nicotinamide derivative, is an oral antianginal drug possessing a nitrate moiety in its structure. This drug is an effective and well-tolerated treatment for various types of angina pectoris. Its structure is characterised by a dual mechanism of action. The nicotinamide moiety acts as an agonist for ATP-sensitive inward rectifier potassium channel 11 (KCNJ11, in complex with its regulatory subunit ABCC9) (Hambrock et al. 1999) and the nitrate group explains its nitrate-like properties (Kinoshita & Sakai 1990, Ahmed 2019).
Literature References
PubMed ID Title Journal Year
10220561 ATP-Sensitive K+ channel modulator binding to sulfonylurea receptors SUR2A and SUR2B: opposite effects of MgADP

Löffler-Walz, C, Delabar, U, Quast, U, Horio, Y, Hambrock, A, Kloor, D, Kurachi, Y

Mol. Pharmacol. 1999
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Orthologous Events
KCNJ11:ABCC9 binds nicorandil (Bos taurus)
KCNJ11:ABCC9 binds nicorandil (Canis familiaris)
KCNJ11:ABCC9 binds nicorandil (Drosophila melanogaster)
KCNJ11:ABCC9 binds nicorandil (Gallus gallus)
KCNJ11:ABCC9 binds nicorandil (Mus musculus)
KCNJ11:ABCC9 binds nicorandil (Rattus norvegicus)
KCNJ11:ABCC9 binds nicorandil (Sus scrofa)
KCNJ11:ABCC9 binds nicorandil (Xenopus tropicalis)
Authored
Jassal, B  (2020-06-17)
Reviewed
Huddart, R  (2022-03-01)
Created
Jassal, B  (2020-06-17)
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