RHOF binds effectors at the plasma membrane

Stable Identifier
R-HSA-9693125
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Active GTP-bound RHOF binds the following effectors:
BAIAP2L1 (Sudhaharan et al. 2016)
BAIAP2L2 (Sudhaharan et al. 2016)
DIAPH1 (Fan et al. 2010)
DIAPH2 (Gorelik et al. 2011)
FARP1 (Fan et al. 2015)

The following candidate RHOF effectors that can localize to cytosol or the plasma membrane were reported by Bagci et al. 2020 to bind active RHOF:
ACTB (Bagci et al. 2020)
ACTN1 (Bagci et al. 2020)
ADD3 (Bagci et al. 2020)
AKAP12 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
BASP1 (Bagci et al. 2020)
CAPZB (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CPNE8 (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
FAM169A (Bagci et al. 2020)
LMNB1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MTMR1 (Bagci et al. 2020)
POTEE (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SENP1 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
STEAP3 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
TOR1AIP1 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Several putative effectors that localize to endoplasmic reticulum, endosomes or the mitochondrial outer membrane were reported to bind active RHOF by Bagci et al. 2020, but as the localization of RHOF to these cellular compartments has not been established, these effectors have not been annotated:
EMD
LBR
LEMD3
LMAN1
PGRMC2
VRK2

The following putative effectors were reported not to bind active RHOF:
DBN1 (Bagci et al. 2020)
EFHD2 (Bagci et al. 2020)
GOLGA8R (Bagci et al. 2020)
HINT2 (Bagci et al. 2020)
MOSPD2 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
20233848 The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells

Scott, A, Mellor, H, Fan, L, Pellegrin, S

J. Cell. Sci. 2010
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP

Nat. Cell Biol. 2020
25668492 The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction

Yan, H, Mellor, H, Fan, L, Pellegrin, S, Morigen, M

Neurosci. Lett. 2015
21119010 Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains

Svitkina, T, Yang, C, Kameswaran, V, Dominguez, R, Gorelik, R

Mol. Biol. Cell 2011
27278019 The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia

Sem, KP, Goh, WI, Liew, HF, Yu, YH, Ahmed, S, Chou, AM, Sudhaharan, T

J. Cell. Sci. 2016
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