Dimerisation of nucleoprotein

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
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Nucleoprotein of SARS-Cov-2 forms stable dimers in solution that partly oligomerize further. The predominant form interacting with RNA is the dimer, with tetramer and higher oligomers appearing temporarily (Wu et al, 2021; Zhao et al, 2021; Slavin et al, 2021; Ye et al, 2020).
Literature References
PubMed ID Title Journal Year
32637943 Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein

Howard, CJ, Hartooni, N, Ghent, CM, Carlson, CR, Morgan, DO, Asfaha, JB

bioRxiv 2020
33794152 Multivalent binding of the partially disordered SARS-CoV-2 nucleocapsid phosphoprotein dimer to RNA

Barbar, E, Forsythe, HM, Reardon, P, Yu, Z, Rolland, AD, Prell, JS, Cooley, RB, Zhu, P, Pinckney, S, Rodriguez Galvan, J

Biophys J 2021
32654247 Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein

Silletti, S, Ye, Q, Corbett, KD, West, AMV

Protein Sci. 2020
34095780 Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain

Valkenburg, SA, Basler, CF, Moyle, AB, Gross, ML, Sweeney-Gibbons, J, Peiris, JSM, Qavi, AJ, Rohrs, HW, Wu, C, Amarasinghe, GK, Wagner, ND, Farnsworth, CW, Kavian, N, Cole, AR, Leung, DW, Hachim, A

iScience 2021
34373319 Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2

Stolovich-Rain, M, Kalisman, N, Baraz, L, Rouvinski, A, Braitbard, M, Friedman, A, Eliyahu, T, Brielle, E, Slavin, M, Wolf, DG, Zohar, K, Linial, M, Schneidman-Duhovny, D, Zamel, J

Proc Natl Acad Sci U S A 2021
33594360 Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

Patterson, GH, Li, Y, Wu, D, Valkov, E, Adão, RC, Schuck, P, Piszczek, G, Zhao, H, Nguyen, A

bioRxiv 2021
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
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