Polyadenylation of SARS-CoV-2 genomic RNA (plus strand)

Stable Identifier
R-HSA-9694471
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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SARS-CoV-2 plus strand genomic RNA (gRNA), like genomic RNAs of SARS-CoV-1 and other coronaviruses, is polyadenylated. The poly(A) tail of gRNA is longer than the poly(A) tail of subgenomic SARS-CoV-2 RNAs (Kim et al. 2020). Coronavirus plus strand gRNAs possess a polyadenylation signal in their 3'UTR and are polyadenylated by an undetermined viral RNA polymerase, possibly nsp8 or nsp12 (Spagnolo and Hogue 2000, Peng et al. 2016, Tvarogova et al. 2019).
Literature References
PubMed ID Title Journal Year
32330414 The Architecture of SARS-CoV-2 Transcriptome

Kim, JW, Kim, D, Lee, JY, Yang, JS, Chang, H, Kim, VN

Cell 2020
Participants
Participates
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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