Nucleoprotein translocates to the ERGIC outer membrane

Stable Identifier
R-HSA-9694568
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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Nucleoprotein translocates to the ERGIC outer membrane
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

As early as 3 hours post-infection, cytoplasmic accumulations of N are formed in infected cells, they colocalize with viral RNA. From 5 hours post-infection on, N can be detected in the Golgi, the budding site (Stertz et al, 2007)
Literature References
PubMed ID Title Journal Year
17210170 The intracellular sites of early replication and budding of SARS-coronavirus

Reichelt, M, Weber, F, Martínez-Sobrido, L, García-Sastre, A, Kochs, G, Kuri, T, Spiegel, M, Stertz, S

Virology 2007
Participants
Input
Output
Participates
as an event of
Inferred From
Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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