3a localizes to the cell membrane

Stable Identifier
R-HSA-9694572
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment, plasma membrane
ReviewStatus
5/5
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3a localizes to the cell membrane
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Coronavirus viroporins (3a) contain cargo sorting motifs in their cytoplasmic domain, so they get localized by the cell's protein transport system to the cell membrane (Tan et al, 2004). SARS-CoV-2 3a functions as potassium ion channel triggering the NLRP3 inflammatory pathway (Xu et al, 2022).
Literature References
PubMed ID Title Journal Year
15194747 A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis

Tan, TH, Hong, W, Teng, E, Tan, YJ, Fielding, BC, Ooi, EE, Lim, SG, Tan, HC, Shen, S, Goh, PY

J. Virol. 2004
35066302 SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Bhaduri-McIntosh, S, Xu, H, Chitre, SA, Loeb, JC, McIntosh, MT, Akinyemi, IA, Lednicky, JA

Virology 2022
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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