nsp8 binds MAP1LC3B

Stable Identifier
R-HSA-9694580
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
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This COVID‑19 event has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The replicase polyprotein 1a of the human severe acute respiratory syndrome coronavirus is post-translationally cleaved by virally encoded proteases to generate non-structural proteins (nsps). Viral nsps induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with host microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Immunofluorescence studies show that nsp8 colocalizes with MAP1LC3B suggesting a binding event (Prentice E. et al 2004).

Literature References
PubMed ID Title Journal Year
15331731 Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins

Prentice, E, McAuliffe, J, Lu, X, Subbarao, K, Denison, MR

J. Virol. 2004
Participants
Participates
Inferred From
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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