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nsp8 binds MAP1LC3B
Stable Identifier
R-HSA-9694580
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
nsp8 binds MAP1LC3B (Homo sapiens)
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This COVID‑19 event has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.
The replicase polyprotein 1a of the human severe acute respiratory syndrome coronavirus is post-translationally cleaved by virally encoded proteases to generate non-structural proteins (nsps). Viral nsps induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with host microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Immunofluorescence studies show that nsp8 colocalizes with MAP1LC3B suggesting a binding event (Prentice E. et al 2004).
Literature References
PubMed ID
Title
Journal
Year
15331731
Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins
McAuliffe, J
,
Prentice, E
,
Lu, X
,
Denison, MR
,
Subbarao, K
J. Virol.
2004
Participants
Input
MAP1LC3B [cytosol]
(Homo sapiens)
nsp8 [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
Output
nsp8:MAP1LC3B [cytosol]
(Homo sapiens)
Participates
as an event of
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Inferred From
nsp8 binds MAP1LC3B (Homo sapiens)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Varusai, TM (2020-05-26)
Reviewed
Acencio, ML (2020-09-09)
Created
Cook, J (2020-07-07)
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