Viral release

Stable Identifier
R-HSA-9694641
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
extracellular region, exocytic vesicle
ReviewStatus
5/5
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Viral release
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Similar to other coronaviruses, SARS-CoV-2 virions are released from the host cell by exocytosis in smooth-walled vesicles (reviewed in Ujike and Taguchi, 2015; Masters, 2006; Fung and Liu, 2019). The nature and details of this export remain to be elucidated.
Literature References
PubMed ID Title Journal Year
25855243 Incorporation of spike and membrane glycoproteins into coronavirus virions

Ujike, M, Taguchi, F

Viruses 2015
16877062 The molecular biology of coronaviruses

Masters, PS

Adv. Virus Res. 2006
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
Participants
Input
Output
Participates
as an event of
Inferred From
Viral release (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Rothfels, K  (2020-07-30)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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