E protein gets N-glycosylated

Stable Identifier
R-HSA-9694790
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
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E protein gets N-glycosylated
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

A minor proportion of the E protein is modified by N-linked glycosylation. This variant appears to be more likely to form multimers, and it shows a different membrane topology than the main variant (Yuan et al, 2006).

Literature References
PubMed ID Title Journal Year
20129637 Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

Feldmann, H, Feldmann, F, Rudd, PM, Stroeher, U, Royle, L, Harvey, DJ, Dwek, RA, Ritchie, G

Virology 2010
Participants
Input
Output
Participates
as an event of
Inferred From
E protein gets N-glycosylated (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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