SPNS2,MFSD2B transport S1P from cytosol to extracellular region

Stable Identifier
R-HSA-9695890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Several different transporters catalyze the secretion of sphingosine 1-phosphate (S1P). S1P is a signaling molecule that regulates many physiological processes in development and the immune system. S1P is produced inside cells, so it must be secreted to exert its effects through its receptors. Protein spinster homolog 2 (SPNS2) is an S1P transporter involved in S1P secretion and regulation of its levels in the lymph, thereby playing a role in lymphocyte trafficking (Nagahashi et al., 2013; Chen et al., 2023; reviewed by Spiegel et al., 2019). MFSD2A exports S1P and is mainly expressed in erythrocytes and platelets, having the function, together with SPNS2, of maintaining the blood-brain barrier (Kobayashi et al., 2018; reviewed by Ghaderi & Levkau, 2023). There is evidence in rats of S1P export by rat homologs of ABCA1, ABCA7, and ABCC1 (reviewed by Reitsema et al., 2014).
Literature References
PubMed ID Title Journal Year
37390971 An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter

Levkau, B, Ghaderi, S

Pharmacol Ther 2023
29563527 MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells

Kawasaki-Nishi, S, Yamaguchi, A, Hisano, Y, Kobayashi, N, Nishi, T, Otsuka, M

Sci Rep 2018
  Sphingosine-1-phosphate transport and its role in immunology

Kok, JW, Bouma, H, Reitsema, V

   
23180825 Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

Ramachandran, S, Yamada, A, Maceyka, M, Nagahashi, M, Spiegel, S, Allegood, JC, Milstien, S, Kim, EY, Hait, NC, Takabe, K

FASEB J. 2013
37224812 Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

Kim, JH, Chen, H, Ahmed, S, Li, X, Dai, Y, Elghobashi-Meinhardt, N, Lee, CH, McDonald, JG, Zhao, H

Cell 2023
30655317 New insights into functions of the sphingosine-1-phosphate transporter SPNS2

Maceyka, M, Milstien, S, Maczis, MA, Spiegel, S

J Lipid Res 2019
Participants
Participates
Catalyst Activity

sphingolipid transporter activity of SPNS2,MFSD2B [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
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Created
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