SPNS2 transports S1P from cytosol to extracellular region

Stable Identifier
R-HSA-9695890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sphingosine 1-phosphate (S1P) is a signaling molecule that regulates many physiological processes in development and the immune system. S1P is produced inside cells so must be secreted to exert its effects through its receptors. Protein spinster homolog 2 (SPNS2) is a S1P transporter involved in S1P secretion and regulation of its levels (Nagahashi et al. 2013).

Literature References
PubMed ID Title Journal Year
23180825 Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

Nagahashi, M, Kim, EY, Yamada, A, Ramachandran, S, Allegood, JC, Hait, NC, Maceyka, M, Milstien, S, Takabe, K, Spiegel, S

FASEB J. 2013
Participants
Participates
Catalyst Activity

sphingolipid transporter activity of SPNS2 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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