RND2 GTPase cycle

Stable Identifier
Homo sapiens
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RND2 (RHON) is an atypical RHO GTPase and the least studied member of the RND subfamily. RND2 is constitutively bound to GTP and lacks GTPase activity. No guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs) or guanine nucleotide dissociation inhibitors (GDIs) act on RND2. RND2 is predominantly expressed in brain, testis and liver (Nobes et al. 1998; Nishi et al. 1999). RND2 regulates neurite outgrowth and branching (Fujita et al. 2002; Kakimoto et al. 2004; Tanaka et al. 2006; Wakita et al. 2011) and migration of newborn neurons within the embryonic cerebral cortex (Nakamura et al. 2006; Heng et al. 2008; Alfano et al. 2011; Pacary et al. 2011; Gladwyn-Ng et al. 2015; Heng et al. 2015).

Literature References
PubMed ID Title Journal Year
18690213 Neurogenin 2 controls cortical neuron migration through regulation of Rnd2

Heng, JI, Nguyen, L, Castro, DS, Zimmer, C, Wildner, H, Armant, O, Skowronska-Krawczyk, D, Bedogni, F, Matter, JM, Hevner, R, Guillemot, F

Nature 2008
16481321 Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity

Tanaka, H, Katoh, H, Negishi, M

J. Biol. Chem. 2006
10101234 RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells

Nishi, M, Takeshima, H, Houtani, T, Nakagawara, K, Noda, T, Sugimoto, T

Brain Res. Mol. Brain Res. 1999
21435554 Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling

Pacary, E, Heng, J, Azzarelli, R, Riou, P, Castro, D, Lebel-Potter, M, Parras, C, Bell, DM, Ridley, AJ, Parsons, M, Guillemot, F

Neuron 2011
12244061 Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching

Fujita, H, Katoh, H, Ishikawa, Y, Mori, K, Negishi, M

J. Biol. Chem. 2002
9531558 A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion

Nobes, CD, Lauritzen, I, Mattei, MG, Paris, S, Hall, A, Chardin, P

J. Cell Biol. 1998
14732713 Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching

Kakimoto, T, Katoh, H, Negishi, M

J. Biol. Chem. 2004
24084125 The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development

Heng, JI, Qu, Z, Ohtaka-Maruyama, C, Okado, H, Kasai, M, Castro, D, Guillemot, F, Tan, SS

Cereb. Cortex 2015
16303198 In vivo function of Rnd2 in the development of neocortical pyramidal neurons

Nakamura, K, Yamashita, Y, Tamamaki, N, Katoh, H, Kaneko, T, Negishi, M

Neurosci. Res. 2006
21768103 The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons

Wakita, Y, Kakimoto, T, Katoh, H, Negishi, M

J. Biol. Chem. 2011
25888806 Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex

Gladwyn-Ng, IE, Li, SS, Qu, Z, Davis, JM, Ngo, L, Haas, M, Singer, J, Heng, JI

Neural Dev 2015
21965613 COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression

Alfano, C, Viola, L, Heng, JI, Pirozzi, M, Clarkson, M, Flore, G, De Maio, A, Schedl, A, Guillemot, F, Studer, M

Development 2011
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