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RND1 binds GTP
Stable Identifier
R-HSA-9696274
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RND1 GTPase cycle (Homo sapiens)
RND1 binds GTP (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RND1 binds GTP with approximately 100 times higher affinity than GDP and is thus considered to be constitutively active (Nobes et al. 1998).
Literature References
PubMed ID
Title
Journal
Year
9531558
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion
Chardin, P
,
Nobes, CD
,
Lauritzen, I
,
Hall, A
,
Paris, S
,
Mattei, MG
J. Cell Biol.
1998
Participants
Input
GTP [cytosol]
RND1 [plasma membrane]
(Homo sapiens)
Output
RND1:GTP [plasma membrane]
(Homo sapiens)
Participates
as an event of
RND1 GTPase cycle (Homo sapiens)
Orthologous Events
RND1 binds GTP (Bos taurus)
RND1 binds GTP (Canis familiaris)
RND1 binds GTP (Danio rerio)
RND1 binds GTP (Gallus gallus)
RND1 binds GTP (Mus musculus)
RND1 binds GTP (Rattus norvegicus)
RND1 binds GTP (Saccharomyces cerevisiae)
RND1 binds GTP (Schizosaccharomyces pombe)
RND1 binds GTP (Sus scrofa)
RND1 binds GTP (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2020-07-14)
Reviewed
Fort, P (2021-02-05)
Created
Orlic-Milacic, M (2020-07-21)
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