PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3

Stable Identifier
R-HSA-9698016
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PTPN11:p-STAT5 has been shown to bind to gamma-interferon activation sites (GAS) in the promoter of BCL2L1 downstream of FLT3-ITD signaling, suggesting that this complex translocates from the cytosol to the nucleus (Nabinger et al, 2013; reviewed in Murphy and Rani, 2015).
Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Boswell, HS, Ramdas, B, Feng, GS, Zeng, L, Kapur, R, He, Y, Liu, Z, Zhang, X, Sandusky, GE, Zhang, ZY, Fukuda, S, Li, XJ, Nabinger, SC, Yu, M, Richine, B, Chan, RJ, Goenka, S, Bowling, JD

Leukemia 2013
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-11-06)
Reviewed
Kazi, JU  (2020-11-06)
Created
Rothfels, K  (2020-08-21)
Cite Us!