sorafenib-sensitive FLT3 mutants [plasma membrane]

Stable Identifier
R-HSA-9699522
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
23392356 The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib

Albers, C, Leischner, H, Verbeek, M, Yu, C, Illert, AL, Peschel, C, von Bubnoff, N, Duyster, J

Leukemia 2013
28077790 FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B, Williams, AB, Young, DJ, Ma, H, Li, L, Levis, M, Brown, P, Small, D

Oncotarget 2017
27132990 Metabolic alterations and drug sensitivity of tyrosine kinase inhibitor resistant leukemia cells with a FLT3/ITD mutation

Huang, A, Ju, HQ, Liu, K, Zhan, G, Liu, D, Wen, S, Garcia-Manero, G, Huang, P, Hu, Y

Cancer Lett. 2016
22858906 Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors

Williams, AB, Nguyen, B, Li, L, Brown, P, Levis, M, Leahy, D, Small, D

Leukemia 2013
24227820 Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants

Galanis, A, Ma, H, Rajkhowa, T, Ramachandran, A, Small, D, Cortes, J, Levis, M

Blood 2014
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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