ponatinib-resistant FLT3 mutants [plasma membrane]

Stable Identifier
R-HSA-9699527
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
26108694 FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors

Smith, CC, Lin, K, Stecula, A, Sali, A, Shah, NP

Leukemia 2015
28077790 FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors

Nguyen, B, Williams, AB, Young, DJ, Ma, H, Li, L, Levis, M, Brown, P, Small, D

Oncotarget 2017
22504184 Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Smith, CC, Wang, Q, Chin, CS, Salerno, S, Damon, LE, Levis, MJ, Perl, AE, Travers, KJ, Wang, S, Hunt, JP, Zarrinkar, PP, Schadt, EE, Kasarskis, A, Kuriyan, J, Shah, NP

Nature 2012
23430109 Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD

Smith, CC, Lasater, EA, Zhu, X, Lin, KC, Stewart, WK, Damon, LE, Salerno, S, Shah, NP

Blood 2013
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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