EML4(1-486)-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9699812
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Echinoderm microtubule-associated protein-like 4, EMAL4_HUMAN, EXON13-EXON 20, variant 1
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
21415216 Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer

Takezawa, K, Okamoto, I, Nishio, K, Jänne, PA, Nakagawa, K

Clin. Cancer Res. 2011
17625570 Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

Soda, M, Choi, YL, Enomoto, M, Takada, S, Yamashita, Y, Ishikawa, S, Fujiwara, S, Watanabe, H, Kurashina, K, Hatanaka, H, Bando, M, Ohno, S, Ishikawa, Y, Aburatani, H, Niki, T, Sohara, Y, Sugiyama, Y, Mano, H

Nature 2007
External Reference Information
External Reference
Gene Names
EML4, C2orf2, EMAPL4
Chain
chain:1-981
Other Identifiers
0002570278
11716652_a_at
11716653_x_at
11716654_a_at
11747005_a_at
16879408
220386_s_at
223068_at
223069_s_at
228674_s_at
2478749
2478750
2478751
2478771
2478772
2478776
2478778
2478780
2478787
2478789
2478791
2478794
2478797
2478801
2478802
2478805
2478806
2478807
2478808
2478810
2478816
2478818
2478826
2478829
2478830
2478833
2478834
2478835
2478836
2478837
2478838
2478839
2478840
2478841
2478842
2478843
2478844
27436
56562_at
8041592
88181_at
A_14_P131775
A_23_P143127
A_24_P273413
GE55919
GO:0000226
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007049
GO:0007052
GO:0007059
GO:0007080
GO:0008017
GO:0008092
GO:0008150
GO:0008608
GO:0016020
GO:0030496
GO:0043014
GO:0043226
GO:0048487
GO:0051276
GO:0051301
GO:0072686
GO:0140014
HMNXSV003035398
HMNXSV003044133
Hs.13472.1.A2_3p_at
ILMN_1718297
PH_hs_0024383
TC02000260.hg
g9506630_3p_a_at
g9957235_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1058 to 1620 at 497 from UniProt:Q9UM73 ALK
Coordinate
497
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
COSMIC
OpenTargets
GeneCards
PRO
Pharos - Targets
GlyGen
PDB
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q8TDX7 NEK7  2 0.508 2
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