ALK fusion proteins [cytosol]

Stable Identifier
R-HSA-9700080
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
10556217 TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations

Hernández, L, Pinyol, M, Hernández, S, Beà, S, Pulford, K, Rosenwald, A, Lamant, L, Falini, B, Ott, G, Mason, DY, Delsol, G, Campo, E

Blood 1999
24613930 Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer

Kelly, LM, Barila, G, Liu, P, Evdokimova, VN, Trivedi, S, Panebianco, F, Gandhi, M, Carty, SE, Hodak, SP, Luo, J, Dacic, S, Yu, YP, Nikiforova, MN, Ferris, RL, Altschuler, DL, Nikiforov, YE

Proc Natl Acad Sci U S A 2014
11310834 Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma

Tort, F, Pinyol, M, Pulford, K, Roncador, G, Hernández, L, Nayach, I, Kluin-Nelemans, HC, Kluin, P, Touriol, C, Delsol, G, Mason, D, Campo, E

Lab Invest 2001
21494621 Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas

Cerchietti, L, Damm-Welk, C, Vater, I, Klapper, W, Harder, L, Pott, C, Yang, SN, Reiter, A, Siebert, R, Melnick, A, Woessmann, W

PLoS One 2011
17625570 Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

Soda, M, Choi, YL, Enomoto, M, Takada, S, Yamashita, Y, Ishikawa, S, Fujiwara, S, Watanabe, H, Kurashina, K, Hatanaka, H, Bando, M, Ohno, S, Ishikawa, Y, Aburatani, H, Niki, T, Sohara, Y, Sugiyama, Y, Mano, H

Nature 2007
8633037 Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

Fujimoto, J, Shiota, M, Iwahara, T, Seki, N, Satoh, H, Mori, S, Yamamoto, T

Proc. Natl. Acad. Sci. U.S.A. 1996
7824924 Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

Morris, SW, Kirstein, MN, Valentine, MB, Dittmer, K, Shapiro, DN, Look, AT, Saltman, DL

Science 1995
22570254 Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer

Ren, H, Tan, ZP, Zhu, X, Crosby, K, Haack, H, Ren, JM, Beausoleil, S, Moritz, A, Innocenti, G, Rush, J, Zhang, Y, Zhou, XM, Gu, TL, Yang, YF, Comb, MJ

Cancer Res 2012
21415216 Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer

Takezawa, K, Okamoto, I, Nishio, K, Jänne, PA, Nakagawa, K

Clin. Cancer Res. 2011
25813404 Novel ALK fusion partners in lung cancer

Iyevleva, AG, Raskin, GA, Tiurin, VI, Sokolenko, AP, Mitiushkina, NV, Aleksakhina, SN, Garifullina, AR, Strelkova, TN, Merkulov, VO, Ivantsov, AO, Kuligina, ESh, Pozharisski, KM, Togo, AV, Imyanitov, EN

Cancer Lett 2015
10934142 TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors

Lawrence, B, Perez-Atayde, A, Hibbard, MK, Rubin, BP, Dal Cin, P, Pinkus, JL, Pinkus, GS, Xiao, S, Yi, ES, Fletcher, CD, Fletcher, JA

Am J Pathol 2000
10706887 Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis

Ma, Z, Cools, J, Marynen, P, Cui, X, Siebert, R, Gesk, S, Schlegelberger, B, Peeters, B, De Wolf-Peeters, C, Wlodarska, I, Morris, SW

Blood 2000
11943732 Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity

Hernández, L, Beà, S, Bellosillo, B, Pinyol, M, Falini, B, Carbone, A, Ott, G, Rosenwald, A, Fernández, A, Pulford, K, Mason, D, Morris, SW, Santos, E, Campo, E

Am. J. Pathol. 2002
24445538 Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

Wiesner, T, He, J, Yelensky, R, Esteve-Puig, R, Botton, T, Yeh, I, Lipson, D, Otto, G, Brennan, K, Murali, R, Garrido, M, Miller, VA, Ross, JS, Berger, MF, Sparatta, A, Palmedo, G, Cerroni, L, Busam, KJ, Kutzner, H, Cronin, MT, Stephens, PJ, Bastian, BC

Nat Commun 2014
10706082 A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma

Trinei, M, Lanfrancone, L, Campo, E, Pulford, K, Mason, DY, Pelicci, PG, Falini, B

Cancer Res 2000
10216106 A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation

Lamant, L, Dastugue, N, Pulford, K, Delsol, G, Mariamé, B

Blood 1999
18593892 Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer

Choi, YL, Takeuchi, K, Soda, M, Inamura, K, Togashi, Y, Hatano, S, Enomoto, M, Hamada, T, Haruta, H, Watanabe, H, Kurashina, K, Hatanaka, H, Ueno, T, Takada, S, Yamashita, Y, Sugiyama, Y, Ishikawa, Y, Mano, H

Cancer Res. 2008
21656749 A novel KIF5B-ALK variant in nonsmall cell lung cancer

Wong, DW, Leung, EL, Wong, SK, Tin, VP, Sihoe, AD, Cheng, LC, Au, JS, Chung, LP, Wong, MP

Cancer 2011
12920229 ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC)

Chikatsu, N, Kojima, H, Suzukawa, K, Shinagawa, A, Nagasawa, T, Ozawa, H, Yamashita, Y, Mori, N

Mod Pathol 2003
Participants
candidates
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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