NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684

Stable Identifier
Reaction [transition]
Homo sapiens
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The following ALK mutants are resistant to inhibiton by NVP-TAE684

ALK L1152R: Sasaki et al, 2011
ALK T1171N: Ceccon et al, 2013
ALK L1198P: Heuckmann et al, 2011
ALK D1203N: Heuckmann et al, 2011
ALK A1234T: George et al, 2008
Literature References
PubMed ID Title Journal Year
21948233 ALK mutations conferring differential resistance to structurally diverse ALK inhibitors

Lovly, CM, Grütter, C, Heynck, S, Sos, ML, Thomas, RK, Peifer, M, Balke-Want, H, Heuckmann, JM, Rauh, D, Koker, M, Weiss, J, Pao, W, Hölzel, M

Clin. Cancer Res. 2011
18923525 Activating mutations in ALK provide a therapeutic target in neuroblastoma

Zozulya, S, George, RE, Gilliland, DG, Morris, SW, Luther, W, London, WB, Hanna, M, Meyerson, M, McGrady, P, Sanda, T, Gregor, VE, Look, AT, Zhang, J, Fröhling, S, Ahn, Y, Diller, L, Webb, TR, Zhou, W, Greulich, H, Gray, NS, Xue, L

Nature 2008
23239810 Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors

Ceccon, M, Mologni, L, Scapozza, L, Bisson, W, Gambacorti-Passerini, C

Mol. Cancer Res. 2013
21791641 A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors

Zheng, W, Lindeman, N, Capelletti, M, Gray, NS, Wong, KK, Christensen, JG, Ercan, D, Jänne, PA, Rodig, SJ, Shimamura, T, Nikiforow, S, Weremowicz, S, Sasaki, T, Okuda, K, Wilner, K, Eck, MJ, Butaney, M, Stumpfova, M, Yanagita, M, Heon, S, Ogino, A, Xiao, Y, Marcoux, JP, Koivunen, J, Lathan, C, Du, J

Cancer Res. 2011
Normal reaction
Functional status

Loss of function of NVP-TAE684-resistant ALK mutants [plasma membrane]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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