Reactome | ALK:MDK dimerization

ALK:MDK dimerization

Stable Identifier

R-HSA-9700137

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Binding of MDK is believed to induce ALK receptor dimerization, similar to other receptor tyrosine kinases (reviewed in Roskoski, 2013; Della Corte et al, 2018). Consistent with this, studies in rat with enforced dimerization of ALK lead to receptor activation, downstream signaling and neurite outgrowth in PC12 cells (Gouzi et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
29455642	Role and targeting of anaplastic lymphoma kinase in cancer Troiani, T, Viscardi, G, Morgillo, F, Fasano, M, Martinelli, E, Ciardiello, F, Della Corte, CM, Di Liello, R	Mol. Cancer	2018
16317043	Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells Vigny, M, Brunet-de Carvalho, N, Moog-Lutz, C, Gouzi, JY	J Cell Sci	2005
23201355	Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition Roskoski, R	Pharmacol. Res.	2013