Reactome | Active ALK binds SHC1

Active ALK binds SHC1

Stable Identifier

R-HSA-9700154

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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SHC1 is recruited to the full-length ALK receptor after activation (Motegi et al, 2004; Degoutin et al, 2007; Kuo et al, 2007). The p46 and p52 isoforms of SHC1 bind to ALK phospho-tyrosine 1507 in a manner that depends on ALK kinase activity (Degoutin et al, 2007). SHC recruitment contributes to activation of MAP kinase signaling and cellular proliferation downstream of ALK signaling, as well as neurite outgrowth and differentiation in PC-12 cells (Souttou et al, 2001; Motegi et al, 2004; Moog-Lutz et al, 2005; Gouzi et al, 2005; Degoutin et al, 2007; reveiwed in Turner and Alexander, 2006; Chiarle et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
15226403	ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth Kotani, M, Motegi, A, Sakuraba, H, Fujimoto, J, Yamamoto, T	J. Cell. Sci.	2004
18097461	The anaplastic lymphoma kinase in the pathogenesis of cancer Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C	Nat. Rev. Cancer	2008
16482213	Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells Turner, SD, Alexander, DR	Leukemia	2006
16317043	Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells Vigny, M, Brunet-de Carvalho, N, Moog-Lutz, C, Gouzi, JY	J Cell Sci	2005
11121404	Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway Carvalho, NB, Raulais, D, Vigny, M, Souttou, B	J. Biol. Chem.	2001
16878150	Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase Kuo, AH, Stoica, GE, Riegel, AT, Wellstein, A	Oncogene	2007
17274988	ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation Vigny, M, Degoutin, J, Gouzi, JY	FEBS Lett.	2007