Reactome | STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]

STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9700467

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Striatin

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        STRN(1-137)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
        
        STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
24475247	Identification of a recurrent STRN/ALK fusion in thyroid carcinomas Pérot, G, Soubeyran, I, Ribeiro, A, Bonhomme, B, Savagner, F, Boutet-Bouzamondo, N, Hostein, I, Bonichon, F, Godbert, Y, Chibon, F	PLoS One	2014
23661334	Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing Majewski, IJ, Mittempergher, L, Davidson, NM, Bosma, A, Willems, SM, Horlings, HM, de Rink, I, Greger, L, Hooijer, GK, Peters, D, Nederlof, PM, Hofland, I, de Jong, J, Wesseling, J, Kluin, RJ, Brugman, W, Kerkhoven, R, Nieboer, F, Roepman, P, Broeks, A, Muley, TR, Jassem, J, Niklinski, J, van Zandwijk, N, Brazma, A, Oshlack, A, van den Heuvel, M, Bernards, R	J. Pathol.	2013

External Reference Information

External Reference

UniProt:O43815 STRN

Gene Names

STRN

Chain

chain:1-780

Reference Genes

BioGPS Gene:6801 STRN

COSMIC (genes):STRN STRN

CTD Gene:6801 STRN

dbSNP Gene:6801 STRN

ENSEMBL:ENSG00000115808 STRN

HGNC:11424 STRN

KEGG:hsa:6801 STRN

Monarch:6801 STRN

NCBI Gene:6801 STRN

OMIM:614765 STRN

UCSC:O43815 STRN

Reference Transcript

RefSeq:NM_003162.4 STRN

Other Identifiers

11730500_at

11755875_a_at

16896374

205520_PM_at

205520_at

215287_PM_at

215287_at

227422_PM_at

227422_at

230734_PM_x_at

230734_x_at

236388_PM_at

236388_at

236980_PM_at

236980_at

242989_PM_at

242989_at

244354_PM_at

244354_at

2548253

2548254

2548256

2548257

2548258

2548260

2548262

2548263

2548265

2548266

2548268

2548270

2548271

2548273

2548275

2548276

2548277

2548279

2548281

2548282

2548283

2548285

2548286

2548289

2548291

2548292

2548293

2548294

2548296

2548299

2548301

2548302

2548303

2548304

2548305

2548317

2548318

2548319

2804784

31736_at

33298_at

4032637

53132_at

60565_at

62989_f_at

62990_r_at

62991_f_at

6801

70775_at

78779_at

8051443

81992_at

82977_at

A_19_P00316199

A_19_P00316200

A_19_P00322614

A_19_P00808033

A_23_P165521

A_32_P174398

A_32_P78904

A_32_P92536

GE81242

GE872109

GO:0005515

GO:0005516

GO:0005737

GO:0005829

GO:0005923

GO:0007626

GO:0008285

GO:0009966

GO:0014069

GO:0016020

GO:0016055

GO:0016358

GO:0030054

GO:0030331

GO:0030425

GO:0030674

GO:0034330

GO:0042995

GO:0043025

GO:0043197

GO:0043226

GO:0044877

GO:0045202

GO:0045211

GO:0048856

GO:0051721

GO:0060090

GO:0070016

GO:0070830

GO:0090443

GO:0098794

HMNXSV003019811

Hs.127486.0.A1_3p_at

Hs.128434.0.S1_3p_at

Hs.135162.0.A1_3p_at

Hs.211253.0.A1_3p_at

Hs.46667.0.A1_3p_at

Hs.5635.0.A1_3p_at

Hs.90787.0.A1_3p_at

ILMN_1749882

ILMN_2129273

PH_hs_0007315

PH_hs_0033959

TC02001736.hg

TC02004160.hg

g4507282_3p_at

Participates

as a component of

STRN(1-137)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

STRN [cytosol]

STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]

p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]

STRN(1-137)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 138 from UniProt:Q9UM73 ALK

Coordinate

138

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
lung adenocarcinoma	DOID:3910	nonsmall cell adenocarcinoma
thyroid carcinoma	DOID:3963	head and neck cancer, Thyroid

Cross References

RefSeq

NP_003153.2

OpenTargets

ENSG00000115808

ENSEMBL

ENSG00000115808, ENST00000263918, ENSP00000263918

Mondo

0005061

GeneCards

STRN

HPA

ENSG00000115808-STRN

PRO

O43815

Pharos - Targets

O43815

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00506 STK25			0.899	8
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.884	11
UniProt:Q13033 STRN3			0.88	12
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-325) [cytosol] (R-HSA-351892) STK24(326-443) [cytosol] (R-HSA-351898) STK24(1-325) [nucleoplasm] (R-HSA-351944)	0.871	7
UniProt:Q9P289 STK26	3	MST4 [cytosol] (R-HSA-351918) MST4(1-305) [cytosol] (R-HSA-351855) MST4(306-416) [cytosol] (R-HSA-351903)	0.864	7
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.84	7
UniProt:Q9BUL8 PDC10			0.823	7
UniProt:Q9P2B4 CT2NL			0.816	8
UniProt:Q9Y3A3 PHOCN			0.794	7
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.788	6
UniProt:Q5VSL9 STRP1			0.773	6
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.725	6
UniProt:Q9NRL3 STRN4			0.725	5
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.725	4
UniProt:P30154 PPP2R1B	2	PPP2R1B [cytosol] (R-HSA-165980) PPP2R1B [nucleoplasm] (R-HSA-166000)	0.725	5
UniProt:Q14BN4 SLMAP			0.706	6
UniProt:Q9ULQ0 STRP2			0.643	4
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.643	3
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.643	5
UniProt:Q8WZ74 CTTB2			0.643	4
UniProt:Q9Y228 T3JAM			0.623	4
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.615	4
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.556	3
UniProt:Q7Z398 ZNF550	1	ZNF550 [nucleoplasm] (R-HSA-1973896)	0.527	2
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.527	2
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:Q9UMS4 PRPF19	1	PRPF19 [nucleoplasm] (R-HSA-5420907)	0.527	2
UniProt:O95819 MAP4K4	1	MAP4K4 [cytosol] (R-HSA-3214893)	0.527	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	2
UniProt:P20155 ISK2			0.527	2
UniProt:O95274 LYPD3	2	cleaved GPI-LYPD3 [extracellular region] (R-HSA-8941013) GPI-LYPD3 [plasma membrane] (R-HSA-8940752)	0.527	2
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	2
UniProt:Q13554 CAMK2B	6	p-T287-CAMK2B [cytosol] (R-HSA-445371) CAMK2B [cytosol] (R-HSA-9611360) p-T287-CAMK2B [endocytic vesicle membrane] (R-HSA-417009) p-T287-CAMK2B [nucleoplasm] (R-HSA-444787) p-T287-CAMK2B [plasma membrane] (R-HSA-432791) p-T287-CAMK2B [endoplasmic reticulum membrane] (R-HSA-9948084)	0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	2
UniProt:P50990 CCT8	5	CCT8 [cytosol] (R-HSA-390449) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894)	0.527	2
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	2
UniProt:Q8N4C8 MINK1	1	MINK1 [cytosol] (R-HSA-2532788)	0.527	3
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2
UniProt:P78371 CCT2	3	CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220)	0.527	2
UniProt:Q9H2K2 TNKS2	1	TNKS2 [cytosol] (R-HSA-3640824)	0.525	2
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.483	3