crizotinib-sensitive ALK mutants [cytosol]

Stable Identifier
R-HSA-9700529
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
24613930 Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer

Altschuler, DL, Nikiforov, YE, Ferris, RL, Hodak, SP, Liu, P, Kelly, LM, Nikiforova, MN, Yu, YP, Dacic, S, Trivedi, S, Luo, J, Barila, G, Panebianco, F, Gandhi, M, Carty, SE, Evdokimova, VN

Proc Natl Acad Sci U S A 2014
28404650 Identification of a novel crizotinib-sensitive BCL11A-ALK gene fusion in a nonsmall cell lung cancer patient

Li, ZW, Deng, WJ, Tian, Q

Eur Respir J 2017
26301689 RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer

Okimoto, RA, Rosell, R, Aisner, DL, Collisson, EA, Doebele, RC, Vaishnavi, A, Riess, JW, Lovly, CM, Blakely, CM, Olivas, V, Ou, SH, Sabnis, A, Bivona, TG, Karachaliou, N, Tulpule, A, Lin, L, Hrustanovic, G, Flanagan, J, Mack, PC, Ichihara, E, Chan, E, Asthana, S, Varella-Garcia, M, Neel, DS, Pazarentzos, E

Nat Med 2015
22570254 Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer

Haack, H, Ren, JM, Gu, TL, Zhu, X, Innocenti, G, Crosby, K, Tan, ZP, Moritz, A, Yang, YF, Ren, H, Rush, J, Beausoleil, S, Comb, MJ, Zhang, Y, Zhou, XM

Cancer Res 2012
24496003 HIP1-ALK, a novel ALK fusion variant that responds to crizotinib

Wang, Z, Christensen, J, Zhang, C, Mao, M, Li, J, Sun, H, Ozeck, M, Fang, DD, Chan, CC, Chen, X, Gu, Q, Sheng, W, Chen, KX, Qian, M, Zhang, B, Xu, Q, Lira, M, Chen, SH

J Thorac Oncol 2014
20979473 EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors

Ishikawa, Y, Soda, M, Ueno, T, Choi, YL, Yamashita, Y, Kimura, H, Takashima, J, Tanio, Y, Nakajima, T, Hamada, T, ALK Lung Cancer Study Group, -, Mitsudomi, T, Yatabe, Y, Haruta, H, Takeuchi, K, Mano, H

N. Engl. J. Med. 2010
27245569 Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Ganesan, S, Hensing, T, Nowak, J, Ou, SH, Allen, J, Ross, JS, Wakelee, H, Schrock, AB, He, J, Zakowski, M, Frampton, GM, Gowen, K, Miller, VA, Menon, S, Chmielecki, J, Ladanyi, M, Molina, JR, Zauderer, M, Klempner, SJ, Peled, N, Firozvi, K, Ali, SM, Stephens, PJ, Fischbach, N, MacMahon, H, Lipson, D, Suh, JH, Sanford, E, Salgia, R, Elvin, JA, Chalmers, Z, Brahmer, JR, Yelensky, R, Kulkarni, A

Oncologist 2016
25393796 Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib

Azada, M, Klempner, SJ, Schrock, AB, Ali, SM, Ou, SH, Stephens, PJ, Miller, VA, Ross, JS, Greenbowe, JR

J Thorac Oncol 2014
25421750 Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma

Piazza, R, Ceccon, M, Giudici, G, Mologni, L, Fontana, D, Gambacorti-Passerini, C, Pirola, A

Mol. Cancer Res. 2015
26001147 BIRC6-ALK, a Novel Fusion Gene in ALK Break-Apart FISH-Negative Lung Adenocarcinoma, Responds to Crizotinib

Ying, J, Zeng, Y, Wu, J, Xu, F, Zhang, W, Jiao, Y, Jiang, P, Guo, L, Shan, L

J Thorac Oncol 2015
32573700 IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma

Chiarle, R, Schleiermacher, G, Lambilliotte, A, Forde, SD, Lobello, C, Pacquement, H, Attarbaschi, A, Probst, NA, Prokoph, N, Malik, V, Barbieri, I, Gambacorti-Passerini, C, Sharma, GG, Klapper, W, Liang, HC, Mologni, L, Woessmann, W, Pospisilova, S, Wang, Q, Pervez, S, Ducray, SP, Geoerger, B, Landman-Parker, J, Turner, SD, Montes-Mojarro, IA, Monahan, JM, Matthews, JD, Kenner, L, Luan, SL, Merkel, O, Vassal, G, Jauch, R, Burke, GAA, Larose, H, Bahnsen, K, Janíková, A, Brugières, L, Lee, LC, Karaca-Atabay, E

Blood 2020
24518094 HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma

Kim, RN, Choi, YL, Song, JY, Han, J, Takeuchi, K, Mao, M, Kim, J, Oh, E, Lira, ME, Choi, SJ, Hong, M

J Thorac Oncol 2014
31388026 Molecular Modeling of ALK L1198F and/or G1202R Mutations to Determine Differential Crizotinib Sensitivity

Chang, HW, Yang, CN, Chuang, YC, Huang, BY

Sci Rep 2019
21502504 Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK

Khan, TM, Iafrate, AJ, Shakespeare, WC, Shaw, AT, Lifshits, E, Rivera, VM, Ebi, H, Engelman, JA, Benes, C, Katayama, R

Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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