TRPA1 tetramer transports Ca2+ from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a homotetrametric channel expressed in the PNS and CNS which involved in pain detection (Moparthy et al. 2014, Paulsen et al. 2015). It acts as a sensor of chemical, thermal, mechanical and somotic stimuli (Zhang et al. 2008).
Literature References
PubMed ID Title Journal Year
20025796 Structure-functional intimacies of transient receptor potential channels

Zaelzer, C, Brauchi, S, Latorre, R

Q. Rev. Biophys. 2009
25855297 Structure of the TRPA1 ion channel suggests regulatory mechanisms

Cheng, Y, Armache, JP, Gao, Y, Julius, D, Paulsen, CE

Nature 2015
25389312 Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

Survery, S, Kreir, M, Simonsen, C, Moparthi, L, Högestätt, ED, Kjellbom, P, Johanson, U, Zygmunt, PM

Proc. Natl. Acad. Sci. U.S.A. 2014
20716668 International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

Clapham, DE, Wu, LJ, Sweet, TB

Pharmacol. Rev. 2010
Catalyst Activity

voltage-gated calcium channel activity of TRPA1 tetramer [plasma membrane]

This event is regulated
Orthologous Events
Cross References
Cite Us!