TRPV1 transports Ca2+ from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a ligand-activated non-selective calcium permeant cation channel involved in the detection of noxious chemical and thermal stimuli. It is involved in the mediation of inflammatory pain and hyperalgesia (Hayes et al. 2000, Cortright et al. 2001).
Literature References
PubMed ID Title Journal Year
20025796 Structure-functional intimacies of transient receptor potential channels

Zaelzer, C, Brauchi, S, Latorre, R

Q. Rev. Biophys. 2009
11243859 The tissue distribution and functional characterization of human VR1

Zou, T, Crandall, M, White, G, Krause, JE, Cortright, DN, Sanchez, JF

Biochem. Biophys. Res. Commun. 2001
11050376 Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

Ellington, K, Sanger, GJ, Clarke, CE, Davis, JB, Meadows, HJ, Terrett, J, Randall, AD, Medhurst, AD, Harries, MH, Barton, AJ, Topp, S, Prinjha, RK, Hayes, P, Jenkins, O, Gunthorpe, MJ, Gloger, IS, Smith, GD, Harrison, DC, Benham, CD, Duckworth, DM, Murdock, P, Cairns, W

Pain 2000
20716668 International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

Clapham, DE, Wu, LJ, Sweet, TB

Pharmacol. Rev. 2010
Catalyst Activity

voltage-gated calcium channel activity of TRPV1 [plasma membrane]

This event is regulated
Orthologous Events
Cross References
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