TRPA1 tetramer binds TRPA1 antagonists

Stable Identifier
R-HSA-9701211
Type
Reaction [binding]
Species
Homo sapiens
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Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a homotetrametric channel expressed in the PNS and CNS which involved in pain detection. It acts as a sensor of chemical, thermal, mechanical and somotic stimuli. The pyrazolone derivatives metamizole (dipyrone), propyphenazone and antipyrine are thought to act as antagonists at the TRPA1 channel to produce analgesic affects (Nassini et al. 2015).

Literature References
PubMed ID Title Journal Year
25765567 The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

Tonello, R, Marone, IM, Patacchini, R, Benemei, S, Geppetti, P, Chiarugi, A, Coppi, E, Preti, D, De Logu, F, Fusi, C, Tuccinardi, T, Materazzi, S, Nassini, R

Br. J. Pharmacol. 2015
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