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p-Y705,S727-STAT3 [nucleoplasm]
Stable Identifier
R-HSA-9701429
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S727,Y705-STAT3, p(Y705, S727)-STAT3, Signal transducer and activator of transcription 3, STAT3_HUMAN, STAT3
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
DNMT1-dependent PTPN6 gene silencing (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
MECP2 binds the STAT5A gene (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
NPM1-ALK- and STAT3-dependent ICOS gene expression (Homo sapiens)
ICOS gene:p-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
NPM1-ALK- and STAT3-dependent TWIST gene expression (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
NPM1-ALK- and p-STAT3-dependent IRF4 gene expression (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
NPM1-ALK- and p-STAT3-dependent NOTCH gene expression (Homo sapiens)
p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
NPM1-ALK-dependent CEBPB gene expression (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
STAT3, DNMT1 and HDAC1 bind PTPN6 gene (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer binds ICOS promoter (Homo sapiens)
ICOS gene:p-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727 STAT3 dimer binds NOTCH gene (Homo sapiens)
p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)
p-Y705, S727 STAT3 dimer:HIF1A gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
CD274 gene expression downstream of ALK signaling (Homo sapiens)
p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
HDACs deacetylate p-STAT3 dimers (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)
p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)
p-Y705, S727 STAT3 dimer:HIF1A gene [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705,S727 STAT3 is acetylated (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Homo sapiens)
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
p-Y705,S727-STAT3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40763 STAT3
Gene Names
STAT3, APRF
Chain
initiator methionine:, chain:2-770
Reference Genes
COSMIC (genes):STAT3 STAT3
dbSNP Gene:6774 STAT3
ENSEMBL:ENSG00000168610 STAT3
Participates
as a component of
p-Y705,S727-STAT3 dimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-Y705-STAT3 [nucleoplasm]
p-Y705-STAT3 [cytosol]
STAT3 [cytosol]
p-Y705-STAT3 [cytosol]
p-Y705,S727-STAT3 [cytosol]
p-S727-STAT3 [cytosol]
p-Y705-STAT3 [nucleoplasm]
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
p-STAT3 [cytosol]
p-STAT3 [nucleoplasm]
Unfolded STAT3 [cytosol]
Inferred To
phospho-dstC [nucleoplasm]
(Dictyostelium discoideum)
phospho-sta-2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-Stat92E [nucleoplasm]
(Drosophila melanogaster)
Homologues of p-Y705,S727-STAT3 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of p-Y705,S727-STAT3 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of p-Y705,S727-STAT3 [nucleoplasm]
(Sus scrofa)
phospho-dstB [nucleoplasm]
(Dictyostelium discoideum)
phospho-STAT3 [nucleoplasm]
(Bos taurus)
phospho-STAT3 [nucleoplasm]
(Canis familiaris)
phospho-STAT3 [nucleoplasm]
(Gallus gallus)
phospho-STAT3 [nucleoplasm]
(Sus scrofa)
phospho-stat3 [nucleoplasm]
(Xenopus tropicalis)
phospho-sta-1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-dstD [nucleoplasm]
(Dictyostelium discoideum)
phospho-Stat3 [nucleoplasm]
(Mus musculus)
phospho-Stat3 [nucleoplasm]
(Rattus norvegicus)
phospho-p-Y705,S727-STAT3 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-Y705,S727-STAT3 [nucleoplasm]
(Dictyostelium discoideum)
phospho-dstA [nucleoplasm]
(Dictyostelium discoideum)
Modified Residues
Name
O-phospho-L-serine at 727
Coordinate
727
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 705
Coordinate
705
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (88)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.919
15
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.908
10
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.873
10
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.842
8
UniProt:P51813 BMX
3
BMX [cytosol]
(R-HSA-351917)
BMX(243-675) [cytosol]
(R-HSA-351875)
BMX(1-242) [cytosol]
(R-HSA-351899)
0.83
8
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.83
9
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.775
9
IntAct:EBI-1550784 CDKN1A
0.725
6
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.649
4
UniProt:P30626 SRI
1
SRI [sarcoplasmic reticulum membrane]
(R-HSA-5490313)
0.635
3
UniProt:Q8TAE8 GADD45GIP1
1
GADD45GIP1 [mitochondrial matrix]
(R-HSA-5368253)
0.635
4
UniProt:Q16236 NFE2L2
13
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
0.625
5
UniProt:P06401 PGR
3
monoSUMO1-K7,K388,K531-PGR [nucleoplasm]
(R-HSA-4341032)
PGR [cytosol]
(R-HSA-8948964)
PGR [nucleoplasm]
(R-HSA-3008952)
0.623
3
UniProt:P18031 PTPN1
2
PTPN1 [endosome membrane]
(R-HSA-9815895)
PTPN1 [cytosol]
(R-HSA-210625)
0.623
2
UniProt:P45984-1 MAPK9
0.602
3
UniProt:Q810M5 ZDH19
0.576
4
UniProt:P23458 JAK1
6
p-Y-JAK1 [cytosol]
(R-HSA-451921)
JAK1 [cytosol]
(R-HSA-451898)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
p-JAK1 [cytosol]
(R-HSA-8950711)
JAK1 [endosome]
(R-HSA-8983168)
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
0.564
2
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-MAP3K7 [cytosol]
(R-HSA-168163)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.558
4
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.556
4
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.556
3
UniProt:Q9DUM3 Q9DUM3
0.556
4
UniProt:P12268 IMPDH2
4
IMPDH2 [secretory granule lumen]
(R-HSA-6803323)
IMPDH2 [extracellular region]
(R-HSA-6806455)
IMPDH2 [ficolin-1-rich granule lumen]
(R-HSA-6803330)
IMPDH2 [cytosol]
(R-HSA-57350)
0.556
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:Q96HA1-2 POM121
0.556
3
UniProt:Q9BXM7 PINK1
5
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-HSA-9834051)
0.547
2
UniProt:Q8N6P7 IL22RA1
2
IL22RA1 [plasma membrane]
(R-HSA-448489)
p-Y-251,p-Y301-IL22RA1 [plasma membrane]
(R-HSA-8987198)
0.547
2
IntAct:EBI-9914958 STAT3
0.527
3
IntAct:EBI-1265559 MYC
0.527
3
UniProt:Q14289 PTK2B
3
PTK2B [cytosol]
(R-HSA-390932)
PTK2B [cytosol]
(R-HSA-5218721)
p-Y-PTK2B [cytosol]
(R-HSA-508515)
0.527
4
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.527
5
UniProt:O75116 ROCK2
2
ROCK2 [cytosol]
(R-HSA-419058)
Activated ROCK2 [cytosol]
(R-HSA-4687775)
0.524
3
UniProt:Q14938-4 NFIX
0.524
3
UniProt:Q14938-3 NFIX
0.524
3
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.512
3
UniProt:Q98PK8 Q98PK8
0.512
3
UniProt:Q9BVP2 GNL3
1
GNL3 [nucleoplasm]
(R-HSA-8869324)
0.508
2
UniProt:Q9ULD0 OGDHL
0.508
2
UniProt:Q13011 ECH1
3
ECH1 [mitochondrial matrix]
(R-HSA-9838037)
ECH1(1-328) [peroxisomal matrix]
(R-HSA-9033140)
ECH1(1-328) [cytosol]
(R-HSA-9033152)
0.508
2
UniProt:P07384 CAPN1
4
CAPN1 [ficolin-1-rich granule lumen]
(R-HSA-6801284)
CAPN1 [extracellular region]
(R-HSA-6806485)
CAPN1 [cytosol]
(R-HSA-3288367)
CAPN1 [plasma membrane]
(R-HSA-3828038)
0.508
2
UniProt:P30084 ECHS1
17
ECHS1 [mitochondrial matrix]
(R-HSA-54125)
A2V ECHS1 [mitochondrial matrix]
(R-HSA-9916688)
T180A ECHS1 [mitochondrial matrix]
(R-HSA-9916687)
A238V ECHS1 [mitochondrial matrix]
(R-HSA-9916686)
A132T ECHS1 [mitochondrial matrix]
(R-HSA-9916665)
G195S ECHS1 [mitochondrial matrix]
(R-HSA-9916681)
K273E ECHS1 [mitochondrial matrix]
(R-HSA-9916680)
R54H ECHS1 [mitochondrial matrix]
(R-HSA-9916676)
I66T ECHS1 [mitochondrial matrix]
(R-HSA-9916659)
D150G ECHS1 [mitochondrial matrix]
(R-HSA-9916674)
A158D ECHS1 [mitochondrial matrix]
(R-HSA-9916689)
C225R ECHS1 [mitochondrial matrix]
(R-HSA-9916672)
N59S ECHS1 [mitochondrial matrix]
(R-HSA-9916684)
A138V ECHS1 [mitochondrial matrix]
(R-HSA-9916683)
E77Q ECHS1 [mitochondrial matrix]
(R-HSA-9916667)
F33S ECHS1 [mitochondrial matrix]
(R-HSA-9916682)
Q159R ECHS1 [mitochondrial matrix]
(R-HSA-9916666)
0.508
3
UniProt:Q92665 MRPS31
1
MRPS31 [mitochondrial inner membrane]
(R-HSA-5368198)
0.508
2
UniProt:P31146 CORO1A
1
CORO1A [cytosol]
(R-HSA-9636432)
0.508
2
UniProt:Q96G01 BICD1
1
BICD1 [cytosol]
(R-HSA-8848104)
0.508
2
UniProt:Q8TE76 MORC4
0.508
2
UniProt:O14874 BCKDK
5
BCKDK [mitochondrial matrix]
(R-HSA-5693129)
R224P BCKDK [mitochondrial matrix]
(R-HSA-9912466)
R174Gfs1* BCKDK [mitochondrial matrix]
(R-HSA-9912469)
L389P BCKDK [mitochondrial matrix]
(R-HSA-9912461)
R156* BCKDK [mitochondrial matrix]
(R-HSA-9912465)
0.508
2
UniProt:Q06520 SULT2A1
1
SULT2A1 [cytosol]
(R-HSA-176559)
0.508
2
UniProt:P22736 NR4A1
2
p-S351-NR4A1 [nucleoplasm]
(R-HSA-199846)
NR4A1 [nucleoplasm]
(R-HSA-199831)
0.508
3
UniProt:P46781 RPS9
2
RPS9 [cytosol]
(R-HSA-72387)
RPS9 [nucleoplasm]
(R-HSA-6790663)
0.508
2
IntAct:EBI-9825772 C-FOS PROMOTER REGION
0.499
2
IntAct:EBI-10039972 MMP2
0.499
2
UniProt:Q9NWQ8 PAG1
2
PAG1 [plasma membrane]
(R-HSA-180500)
p-Y317-PAG1 [plasma membrane]
(R-HSA-180494)
0.499
7
UniProt:P32119 PRDX2
2
p-T89-PRDX2 [cytosol]
(R-HSA-8868574)
PRDX2 [cytosol]
(R-HSA-3341292)
0.499
4
IntAct:EBI-1108795 NPM
0.499
2
IntAct:EBI-9980755 MIR-155
0.499
2
IntAct:EBI-10952519 STAT
0.499
4
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.499
5
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.488
2
UniProt:Q5VWN6 TASO2
0.488
2
IntAct:EBI-10696506 MPZL1
0.488
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
UniProt:Q8NEC7 GSTCD
0.488
2
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.488
2
UniProt:P35219 CAH8
0.488
2
UniProt:Q9Y4J8-9 DTNA
0.488
2
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.488
2
UniProt:P27986-2 PIK3R1
0.488
2
UniProt:Q9Y3P9 RABGAP1
1
RABGAP1 [cytosol]
(R-HSA-8854144)
0.488
2
UniProt:Q9NVE4 CCD87
0.488
2
UniProt:Q96DZ7 T4S19
0.488
2
UniProt:Q8IZQ1 WDFY3
0.488
2
UniProt:Q6P1L5 F117B
0.488
2
UniProt:Q86WK9 PAQR7
0.488
2
UniProt:Q14847 LASP1
0.488
2
UniProt:Q03181-2 PPARD
0.488
2
UniProt:Q3KNS6 ZN829
0.488
2
UniProt:Q7L591-3 DOK3
0.488
2
UniProt:Q9UBX0 HESX1
0.488
2
UniProt:Q6ZVU3 Q6ZVU3
0.488
2
UniProt:Q9Y2X9 ZN281
0.488
2
UniProt:Q15672 TWIST1
1
TWIST1 [nucleoplasm]
(R-HSA-445442)
0.488
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.488
2
UniProt:P07949 RET
2
RET [plasma membrane]
(R-HSA-8853797)
p-5Y-RET [plasma membrane]
(R-HSA-8854162)
0.483
3
UniProt:O95661 DIRA3
0.463
3
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.463
4
UniProt:P35232 PHB
2
PHB [cytosol]
(R-HSA-5672944)
PHB [mitochondrial inner membrane]
(R-HSA-8953720)
0.463
2
UniProt:Q9UBE8 NLK
3
NLK [cytosol]
(R-HSA-4411330)
p-T298-NLK [cytosol]
(R-HSA-4411398)
p-T298-NLK [nucleoplasm]
(R-HSA-4411376)
0.462
2
UniProt:Q99062 CSF3R
5
CSF3R [plasma membrane]
(R-HSA-6787734)
p-4Y-CSF3R [plasma membrane]
(R-HSA-9674543)
p-4Y-CSF3R [endocytic vesicle membrane]
(R-HSA-9705736)
K48polyUb-K655,p-4Y-CSF3R [endocytic vesicle membrane]
(R-HSA-9705727)
K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane]
(R-HSA-9707928)
0.462
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.462
3
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