AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter

Stable Identifier
R-HSA-9701549
Type
Reaction [binding]
Species
Homo sapiens
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Acetylated, phosphorylated STAT3 and SIN3A bind to the PRDM1 promoter downstream of ALK signaling as assessed by ChIP in NPM-ALK cells (Gambi et al, 2019). Binding contributes to transcriptional repression of PRDM1, also known as BLIMP1, a transcription factor with roles in innate and adaptive immune response in B and T cells (reviewed in Boi et al, 2015).

Literature References
PubMed ID Title Journal Year
30692217 The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3

Verma, A, Inghirami, G, Gambi, G, Wang, R, Elemento, O, Basso, V, Di Simone, E, Mondino, A, Ponzoni, M, Icardi, L, Ricci, L

Cancer Res. 2019
25115512 PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas

Inghirami, G, Bertoni, F, Zucca, E, Boi, M

Leuk. Lymphoma 2015
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