CD274 gene expression downstream of ALK signaling

Stable Identifier
R-HSA-9701562
Type
Reaction [omitted]
Species
Homo sapiens
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ALK signaling promotes expression of the CD274 gene by stimulating STAT3 binding to its promoter (Marzec et al, 2008). CD274 is a plasma membrane immunosuppressive protein that stimulates immune evasion by binding to its ligand CD279 (reviewed in Kythreotou et al, 2017).

Literature References
PubMed ID Title Journal Year
29097600 PD-L1

Kythreotou, A, Siddique, A, Mauri, FA, Bower, M, Pinato, DJ

J. Clin. Pathol. 2018
19088198 Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Marzec, M, Zhang, Q, Goradia, A, Raghunath, PN, Liu, X, Paessler, M, Wang, HY, Wysocka, M, Cheng, M, Ruggeri, BA, Wasik, MA

Proc. Natl. Acad. Sci. U.S.A. 2008
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