HDACs deacetylate p-STAT3 dimers

Stable Identifier
R-HSA-9701565
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HDAC1, 2, and 3 deacetylate lysine 685 of STAT3. Deacetylation reduces the transcriptional activity of STAT3 dimers as assessed by reporter gene assays in HEK293 cells (Yuan et al, 2005).

Literature References
PubMed ID Title Journal Year
15653507 Stat3 dimerization regulated by reversible acetylation of a single lysine residue

Yuan, ZL, Guan, YJ, Chatterjee, D, Chin, YE

Science 2005
Participants
Participates
Catalyst Activity

protein deacetylase activity of HDAC1,2,3 [nucleoplasm]

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