HDACs deacetylate p-STAT3 dimers

Stable Identifier
R-HSA-9701565
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HDACs deacetylate p-STAT3 dimers
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HDAC1, 2, and 3 deacetylate lysine 685 of STAT3. Deacetylation reduces the transcriptional activity of STAT3 dimers as assessed by reporter gene assays in HEK293 cells (Yuan et al, 2005).
Literature References
PubMed ID Title Journal Year
15653507 Stat3 dimerization regulated by reversible acetylation of a single lysine residue

Yuan, ZL, Chin, YE, Guan, YJ, Chatterjee, D

Science 2005
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Catalyst Activity

protein lysine deacetylase activity of Histone deacetylase [nucleoplasm]

Physical Entity
Histone deacetylase [nucleoplasm] (Homo sapiens)
Activity
protein lysine deacetylase activity (GO:0033558)
Orthologous Events
HDACs deacetylate p-STAT3 dimers (Bos taurus)
HDACs deacetylate p-STAT3 dimers (Caenorhabditis elegans)
HDACs deacetylate p-STAT3 dimers (Canis familiaris)
HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)
HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)
HDACs deacetylate p-STAT3 dimers (Gallus gallus)
HDACs deacetylate p-STAT3 dimers (Mus musculus)
HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)
HDACs deacetylate p-STAT3 dimers (Sus scrofa)
HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-26)
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