STAT3 nuclear events downstream of ALK signaling

Stable Identifier
R-HSA-9701898
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Activation of the STAT3 pathway downstream of ALK signaling contributes to cellular survival by modulating expression of a number of genes involved in apoptosis, immune response and angiogenesis (reviewed in Werner et al, 2009). The STAT3 pathway is particularly important in ALK+ cancers that express ALK fusion proteins, where STAT3 contributes to the repression of a number of tumor suppressor genes, highlighting its role as a critical oncogene (reviewed in Yu et al, 2014; Guanizo et al, 2018).

Literature References
PubMed ID Title Journal Year
27879258 Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target

Zhao, C, Wasik, MA, Zhang, Q, Werner, MT

Blood 2017
25342631 Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H

Nat. Rev. Cancer 2014
29873274 STAT3: a multifaceted oncoprotein

Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD

Growth Factors 2018
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!