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STAT5A [nucleoplasm]
Stable Identifier
R-HSA-9701901
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Signal transducer and activator of transcription 5A, STA5A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)
STAT5A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42229 STAT5A
Gene Names
STAT5A, STAT5
Chain
chain:1-794
Reference Genes
BioGPS Gene:6776 STAT5A
COSMIC (genes):STAT5A STAT5A
CTD Gene:6776 STAT5A
dbSNP Gene:6776 STAT5A
ENSEMBL:ENSG00000126561 STAT5A
HGNC:11366 STAT5A
KEGG:hsa:6776 STAT5A
Monarch:6776 STAT5A
NCBI Gene:6776 STAT5A
OMIM:601511 STAT5A
UCSC:P42229 STAT5A
Reference Transcript
RefSeq:NM_003152.3 STAT5A
RefSeq:NM_001288719.1 STAT5A
RefSeq:NM_001288718.1 STAT5A
RefSeq:NM_001288720.1 STAT5A
Other Identifiers
11717178_a_at
11745364_a_at
16834273
203010_PM_at
203010_at
3721659
3721660
3721661
3721662
3721663
3721664
3721665
3721667
3721669
3721670
3721671
3721672
3721673
3721674
3721676
3721678
3721679
3721680
3721681
3721683
3721684
3721685
3721686
3721687
3721688
3721689
3721690
3721691
3757791
3757799
3757800
3757801
3757807
40458_at
506_s_at
6776
75183_at
8007212
A_14_P103776
A_14_P118146
A_23_P207367
A_24_P173088
GE81241
GO:0000785
GO:0000978
GO:0000981
GO:0001938
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006790
GO:0006952
GO:0007165
GO:0007166
GO:0007259
GO:0007595
GO:0019221
GO:0019530
GO:0030154
GO:0030222
GO:0035723
GO:0035771
GO:0038026
GO:0038043
GO:0038110
GO:0038111
GO:0038113
GO:0038156
GO:0040014
GO:0042127
GO:0043226
GO:0043434
GO:0043536
GO:0045944
GO:0048856
GO:0060397
GO:0090575
GO:0140110
GO:0140297
GO:2000329
HMNXSV003024861
HMNXSV003050095
ILMN_1753547
PH_hs_0025570
TC17000523.hg
U43185_s_at
g4507256_3p_at
Participates
as an output of
ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)
Other forms of this molecule
STAT5A [cytosol]
p-Y694-STAT5A [cytosol]
p-Y694-STAT5A [nucleoplasm]
Cross References
RefSeq
NP_001275647.1
,
NP_001275648.1
,
NP_001275649.1
,
NP_003143.2
Guide to Pharmacology - Targets
3221
ENSEMBL
ENSP00000468749
,
ENSP00000443107
,
ENST00000590949
,
ENST00000345506
,
ENSP00000503262
,
ENSP00000504449
,
ENST00000677301
,
ENST00000676585
,
ENST00000546010
,
ENSP00000341208
OpenTargets
ENSG00000126561
ZINC - Substances
STA5A_HUMAN
ZINC target
P42229
PRO
P42229
GlyGen
P42229
PDB
7UC7
,
7UC6
,
7UBT
,
7TVB
,
7TVA
ZINC - Investigational
STA5A_HUMAN
HPA
ENSG00000126561-STAT5A
Pharos - Targets
P42229
ZINC - Predictions - Purchasable
STA5A_HUMAN
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08559 PDHA1
1
PDHA1 [mitochondrial matrix]
(R-HSA-69966)
0.643
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.635
4
UniProt:P18031 PTPN1
2
PTPN1 [endosome membrane]
(R-HSA-9815895)
PTPN1 [cytosol]
(R-HSA-210625)
0.558
2
UniProt:Q9UGK3 STAP2
2
STAP2 [cytosol]
(R-HSA-8848028)
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
0.556
11
UniProt:Q99081 TCF12
1
TCF12 [nucleoplasm]
(R-HSA-445670)
0.556
3
UniProt:Q99490-2 AGAP2
0.556
3
UniProt:O60603 TLR2
3
TLR2 [plasma membrane]
(R-HSA-167992)
TLR2 [secretory granule membrane]
(R-HSA-6804777)
TLR2 [plasma membrane]
(R-HSA-9637646)
0.527
2
UniProt:Q15119 PDK2
1
PDK2(?-407) [mitochondrial matrix]
(R-HSA-203943)
0.527
2
UniProt:P10515 DLAT
4
Lipo-K259-DLAT [mitochondrial matrix]
(R-HSA-69969)
AcetyllipoH2-K132,K259-DLAT [mitochondrial matrix]
(R-HSA-9861594)
LipoH2-K259-DLAT [mitochondrial matrix]
(R-HSA-9861664)
DLAT [mitochondrial matrix]
(R-HSA-6792585)
0.527
2
UniProt:P51692 STAT5B
4
p-STAT5B [cytosol]
(R-HSA-8983127)
p-Y699-STAT5B [nucleoplasm]
(R-HSA-508016)
p-Y699-STAT5B [cytosol]
(R-HSA-507939)
STAT5B [cytosol]
(R-HSA-380737)
0.527
3
UniProt:Q8IXQ5 KLHL7
0.527
2
UniProt:Q15120 PDK3
1
PDK3(?-406) [mitochondrial matrix]
(R-HSA-203940)
0.527
3
UniProt:O00330 PDHX
1
PDHX [mitochondrial matrix]
(R-HSA-70059)
0.527
2
UniProt:P11177 PDHB
1
PDHB [mitochondrial matrix]
(R-HSA-69967)
0.527
3
IntAct:EBI-1566868 IL2RA
0.525
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.524
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.488
2
UniProt:Q8TAK6 OLIG1
0.488
2
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.462
2
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