Reactome | RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]

RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9702002

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 SUMO-protein ligase RanBP2 ecNumber evidence="29 31 33 37 44"2.3.2.-/ecNumber, RBP2_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18701132	An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features Chen, ST, Lee, JC	Hum. Pathol.	2008
21164297	Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK Wang, WL, Hornick, JL, Roy, A, Coffin, CM, Mariño-Enríquez, A, Lazar, AJ, Lopez-Terrada, D, Fletcher, CD	Am. J. Surg. Pathol.	2011
27874193	ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma Fletcher, JA, Hornick, JL, Lee, CT, Ou, WB, Mariño-Enríquez, A, Li, CF, Lee, JC, Zhu, MJ, Huang, HY	J. Pathol.	2017

External Reference Information

External Reference

UniProt:P49792 RANBP2

Gene Names

RANBP2, NUP358

Chain

chain:1-3224

Reference Genes

BioGPS Gene:5903 RANBP2

COSMIC (genes):RANBP2 RANBP2

CTD Gene:5903 RANBP2

dbSNP Gene:5903 RANBP2

ENSEMBL:ENSG00000153201 RANBP2

ENSEMBL_homo_sapiens_GENE:ENSG00000153201.17 RANBP2

HGNC:9848 RANBP2

KEGG Gene (Homo sapiens):5903 RANBP2

Monarch:5903 RANBP2

NCBI Gene:5903 RANBP2

OMIM:601181 RANBP2

UCSC:P49792 RANBP2

Reference Transcript

RefSeq:NM_006267.4 RANBP2

Other Identifiers

11722814_s_at

11722815_at

11722816_at

11754283_s_at

11758005_s_at

16884126

201711_PM_x_at

201711_x_at

201712_PM_s_at

201712_s_at

201713_PM_s_at

201713_s_at

226922_PM_at

226922_at

2492220

2492221

2492223

2492290

2492297

2492302

2492303

2492304

2492305

2492307

2492308

2492310

2492312

2492313

2492315

2492316

2492317

2498744

2498745

2498746

2498747

2498748

2498750

2498751

2498752

2498753

2498755

2498757

2498758

2498759

2498763

2498764

2498765

2499126

2499159

2499160

2499162

2499163

2499164

2499165

2499166

2499167

2499169

2499170

2499171

2499173

2499175

2499177

2499178

2499179

2499180

2499181

2499182

2499183

2499184

2499185

2499186

2499187

2499188

2499189

2499190

2499191

2499193

2499194

2499195

2499196

2499197

2499201

2499202

2499203

2499204

2499205

2499206

2499207

2499208

2499209

2499210

2499211

2499235

2499236

2499237

2499619

2499620

2499621

2499623

2499624

2499625

2499626

2499631

2499633

2499634

2499635

2499637

2499640

2499641

2499642

2499643

2499644

2499645

2499648

2499649

2499650

2563430

2563431

2563432

2563434

2563436

2563437

2563439

2563440

2563442

2563444

2563446

2563447

2563448

2563452

2563455

2563456

2563458

2569096

2569097

2569098

2569102

2569103

2569104

2569105

2569107

2569109

2569110

2569111

2569112

2569116

2569117

2569118

2569119

2569120

2570484

2570486

2570488

2570490

2570491

2570493

2570494

2570495

2570498

2570499

2570500

2570501

2570503

2570510

2570511

2570512

2570513

2570515

2570516

2570517

2570556

2570557

2570559

2570561

2570564

2570566

2570567

2570569

2570570

2570571

2570574

2570576

2570577

2570578

2570580

2570588

2570589

2570590

2570591

2570593

2570594

2570595

2571300

2571302

2571303

2571305

2571306

2571308

2571309

2571310

2571313

2571315

2571316

2571317

2571319

2571326

2571327

2571328

2571329

2571331

2571332

2571333

32788_at

51177_at

5903

8044161

8044263

8044304

8054414

8054532

8054557

8054676

A_14_P113906

A_23_P131664

A_24_P350890

A_33_P3272390

A_33_P3308740

D42063_at

GE61553

GE80234

GO:0000413

GO:0001975

GO:0003723

GO:0003755

GO:0003824

GO:0005096

GO:0005515

GO:0005634

GO:0005635

GO:0005642

GO:0005643

GO:0005654

GO:0005737

GO:0005829

GO:0005975

GO:0006111

GO:0006457

GO:0006607

GO:0006807

GO:0006886

GO:0006913

GO:0015031

GO:0016020

GO:0016740

GO:0016853

GO:0016925

GO:0019789

GO:0031267

GO:0031965

GO:0036211

GO:0042405

GO:0043170

GO:0043226

GO:0043231

GO:0044238

GO:0044614

GO:0044615

GO:0044877

GO:0046872

GO:0046907

GO:0051028

GO:0051168

GO:0051642

GO:0061665

GO:0098772

GO:0106068

GO:0140096

GO:1990723

HMNXSV003021186

HMNXSV003037067

Hs.199179.0.S1_3p_s_at

Hs.28248.0.A1_3p_at

ILMN_1654866

ILMN_2320574

PH_hs_0011701

TC02000668.hg

g6382078_3p_a_at

g924266_3p_a_at

Participates

as a candidate of

ALK fusion proteins [cytosol] (Homo sapiens)

as a component of

RANBP2(1-867)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]

monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]

RANBP2 [nuclear envelope]

RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol]

RANBP2 [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 868 from UniProt:Q9UM73 ALK

Coordinate

868

Disease

Name	Identifier	Synonyms
epithelioid inflammatory myofibroblastic sarcoma	DOID:0080372

Cross References

RefSeq

NP_006258.3

COSMIC

COSF415

OpenTargets

ENSG00000153201

HPA

ENSG00000153201-RANBP2

GeneCards

P49792

Ensembl

ENSG00000153201, ENSP00000283195, ENST00000283195

PRO

P49792

Pharos - Targets

P49792

Orphanet

17981

HMDB Protein

HMDBP08534

PDB

5CLL, 7MNU, 1XKE, 7MNV, 4LQW, 5CLQ, 7MNW, 2LAS, 7MNX, 7MNJ, 7MNL, 4I9Y, 7MNK, 7R5J, 3UIO, 7MNY, 7R5K, 1Z5S, 7MNM, 7MNZ, 4GA0, 3UIP, 7MNO, 7MNN, 7MNP, 7MNQ, 1RRP, 4L6E, 3UIN, 7MNR, 7MNS, 7MNT

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.861	7
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.854	7
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.713	5
UniProt:O60260 PARK2	4	polyUb-PARK2 [cytosol] (R-HSA-5689094) p-S9-PRKN [cytosol] (R-HSA-9793481) p-S65-PRKN [cytosol] (R-HSA-9834954) PRKN [cytosol] (R-HSA-201579)	0.639	11
UniProt:Q921C5-1 BICD2			0.633	4
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.547	2
UniProt:Q9BPX7 CG025			0.544	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P61769 B2M	11	B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.527	4
UniProt:O14524 NEMP1			0.527	3
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.463	3

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